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Spectrum of malignant and premalignant skin lesions in 505 adult subjects at risk of skin cancers
Patients at risk of skin cancers can develop varying types of cutaneous malignancies. However, some subjects may develop only one type of lesion. In...
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Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
BackgroundBronchial premalignant lesions (PMLs) are composed primarily of cells resembling basal epithelial cells of the airways, which through...
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A comprehensive update: gastrointestinal microflora, gastric cancer and gastric premalignant condition, and intervention by traditional Chinese medicine
With the recent upsurge of studies in the field of microbiology, we have learned more about the complexity of the gastrointestinal microecosystem....
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SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN
SOX2 expression in high-grade cervical intraepithelial neoplasia (CIN3) and cervical squamous cell carcinoma is increased compared to that in the...
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TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions
BackgroundTo improve the efficiency of early diagnosis systems for cervical cancer, the use of cellular and viral markers for identifying...
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Noncoding RNAs in oral premalignant disorders and oral squamous cell carcinoma
BackgroundOral squamous cell carcinoma (OSCC) has the highest mortality rate among all head and neck cancers and a relatively low five-year survival...
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Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy
BackgroundElevated mammographic breast density is a strong breast cancer risk factor with poorly understood etiology. Increased deposition of...
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Combination immunotherapy with synthetic long peptides and chemotherapy or PD-1 blocker for cancers caused by human papilloma virus type 16
Therapeutic vaccination of premalignant conditions and of different stages of cancer can be accomplished with several platforms including DNA...
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Identification of cancer driver mutations in liquid-based cytology samples for the screening of endometrial diseases
BackgroundEndometrial cancer (EC) is one of the leading causes of cancer death among women and early detection is crucial for its successful...
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Breast cancer risk in papilloma patients: Osteopontin splice variants indicate prognosis
BackgroundPapillomas of the breast pose challenges for treatment decisions as their risk for transformation to breast cancer is low but not...
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Circulating levels of PCSK9, ANGPTL3 and Lp(a) in stage III breast cancers
Background / synopsisCholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3...
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Total RNA sequencing reveals gene expression and microbial alterations shared by oral pre-malignant lesions and cancer
AbstractHead and neck cancers are a complex malignancy comprising multiple anatomical sites, with cancer of the oral cavity ranking among the...
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Type distribution of human papillomaviruses in ThinPrep cytology samples and HPV16/18 E6 gene variations in FFPE cervical cancer specimens in Fars province, Iran
BackgroundThere exists strong evidence that human papillomavirus (HPV) is associated with cervical cancer (CC). HPV E6 is a major oncogene whose...
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Advances in cutaneous squamous cell carcinoma
Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise transformation from healthy epithelium to premalignant...
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Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers
BackgroundGingivobuccal complex oral squamous cell carcinoma (GBC-OSCC) is an aggressive malignancy with high mortality often preceded by...
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Cancer Immunoprevention: Current Status and Future Directions
Cancer is one of the most serious diseases affecting health and the second leading cause of death worldwide. Despite the development of various...
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The genomic architectures of tumour-adjacent tissues, plasma and saliva reveal evolutionary underpinnings of relapse in head and neck squamous cell carcinoma
BackgroundHead and neck squamous cell carcinoma (HNSCC) is characterised by a dismal prognosis; nonetheless, limited studies have unveiled the...
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Using a combination of superb microvascular imaging and other auxiliary ultrasound techniques to increase the accuracy of gray-scale ultrasound for breast masses
BackgroundBreast ultrasound is highly sensitive, but its specificity is not as high for detecting malignant lesions. Auxiliary modalities like...
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Premalignant Disorders of the Breast in Pregnancy and Lactation
Papillomas, atypical hyperplasias, and lobular carcinoma in situ of the breast Breasts are not malignant tumors, but present serious management...
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Profiling small RNAs in fecal immunochemical tests: is it possible?
Fecal microRNAs represent promising molecules with potential clinical interest as non-invasive diagnostic and prognostic biomarkers. Colorectal...
