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Preformulation in Drug Product Design
This chapter provides an overview of the factors that are considered in dosage form design, including physicochemical properties of drugs, drug...
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Preformulation of 3D Printable Pharmaceutical Dosage Forms
Preformulation studies are designed to ensure a pharmaceutical dosage form will be produced within the best scenario of materials and processing...
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Preformulation Studies to Guide the Production of Medicines by Fused Deposition Modeling 3D Printing
Fused deposition modeling (FDM) 3D printing has demonstrated high potential for the production of personalized medicines. However, the heating at...
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Preformulation and evaluation of multi-layer tablets
BackgroundThe tablet is the most common drug formulation in the pharmaceutical industry. With the invention of new pharmaceutical tablet compression...
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Preformulation Characterization of Griffithsin, a Biopharmaceutical Candidate for HIV Prevention
Griffithsin (GRFT) has shown potent anti-HIV activity, and it is being developed as a drug candidate for HIV prevention. Successful implementation...
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Preformulation and characterization of raloxifene-loaded lipid nanoparticles for transdermal administration
AbstractTransdermal administration of raloxifene hydrochloride (RLX)-loaded nanostructured lipid carriers (NLCs) has been proposed to circumvent its...
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Investigation of 1,2-Dimyristoyl-sn-Glycero-3-Phosphoglycerol-Sodium (DMPG-Na) Lipid with Various Metal Cations in Nanocochleate Preformulation: Application for Andrographolide Oral Delivery in Cancer Therapy
This study aimed at carrying out a preformulation investigation of nanocochleates (NCs) and develop andrographolide-loaded nanocochleates....
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Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation
Pharmaceutical systems and products almost always include solid-state ingredients either during manufacture or as the dosage form itself. Thus...
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Nanoparticle Products for the Eye: Preformulation, Formulation, and Manufacturing Considerations
Recent developments in nanotechnology have provided an unprecedented opportunity to improve the prevention and treatment of ocular diseases. Because...
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Clozapine-loaded nanocapsules improve antipsychotic activity in rats: building a sequential PopPK/PD model to discriminate nanocarriers in the preformulation step
PurposeWe investigated the impact of nanoformulations on the dose-exposure-response relationship of clozapine (CZP), a low-solubility antipsychotic...
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Microparticle Products for the Eye: Preformulation, Formulation, and Manufacturing Considerations
Posterior segment diseases are one of the major causes of blindness. Their treatments require successive intraocular injections being associated to...
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Development of Lipid Polymer Hybrid Drug Delivery Systems Prepared by Hot-Melt Extrusion
This study sought to develop polymer-lipid hybrid solid dispersions containing the poorly soluble drug lopinavir (LPV) by hot-melt extrusion (HME)....
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Preformulation in Drug Product Design
This chapter provides an overview of the factors that are considered in dosage form design, including physicochemical properties of drugs, drug...
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Development, Quality by Design-Based Optimization, and Stability Assessment of Oral Liquid Formulations Containing Baclofen for Hospital Use
The absence of oral liquid pharmaceutical forms appropriate for use in pediatric and adult patients with difficulty swallowing is a public health...
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Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma
Preformulation studies on tofacitinib citrate, a small molecule JAK3 specific inhibitor, have not been previously reported in literature. We...
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Optimizing the Formulation of Poorly Water-Soluble Drugs
With as high as 90% of drugs in the development phase and 40% of marketed products exhibiting poor aqueous solubility, the ability to successfully...
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Solution-Based Dosage Forms and Sterile Products
This chapter expands upon the concept of drug solubility and dissolution as it relates to dosage form design. Excipients utilized in solution-based...
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Quality-by-Design Approach Development, Characterization, and In Vitro Release Mechanism Elucidation of Nanostructured Lipid Carriers for Quetiapine Fumarate Oral Delivery
PurposeThe objective of this work was to develop a new nanostructured lipid carrier (NLC) formulation for the oral delivery of quetiapine fumarate...
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Pharmaceutical Quality by Design (QbD) Overview and Major Elements
The risk-based approach initiative for pharmaceutical development initiated in 2004 by the Food and Drug Administration (FDA, USA) paved the way for...
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Digital Pharmaceutical Sciences
Artificial intelligence (AI) and machine learning, in particular, have gained significant interest in many fields, including pharmaceutical sciences....
