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Zebrafish: A Versatile Animal Model to Study Tumorigenesis Process and Effective Preclinical Drug Screening for Human Cancer Research
Animal model systems are very important for preclinical evaluation of drugs and also to understand underlined pathophysiology and cellular cross...
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An animal-free preclinical drug screening platform based on human precision-cut kidney slices
ObjectiveRenal fibrosis is one of the main pathophysiological processes underlying the progression of chronic kidney disease and kidney allograft...
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Available Preclinical Tools for Neuroblastoma
Neuroblastoma is the most predominant and deadly cancer in infants and in young children and contributes significantly to childhood cancer deaths....
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Preclinical Models of Meningioma
The management of clinically aggressive meningiomas remains challenging due to limited treatment options aside from surgical removal and...
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Patient-Derived Xenografts: A Valuable Preclinical Model for Drug Development and Biomarker Discovery
Patient-derived xenografts (PDXs), established by implanting patient tumor cells into immunodeficient mice, offer a platform for faithfully...
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AI-Driven Enhancements in Drug Screening and Optimization
The greatest challenge in drug discovery remains the high rate of attrition across the different phases of the process, which cost the industry...
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Antigen identification strategies and preclinical evaluation models for advancing tuberculosis vaccine development
In its myriad devastating forms, Tuberculosis (TB) has existed for centuries, and humanity is still affected by it. Mycobacterium tuberculosis ( M....
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Prostate Cancer Organoids for Tumor Modeling and Drug Screening
Prostate cancer (PCa) is the second most common malignancy and the fifth leading cause of cancer death in men worldwide. Despite its prevalence, the...
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Preclinical models in head and neck squamous cell carcinoma
Head and neck cancer is the sixth most frequent cancer type. Drug resistance and toxicity are common challenges of the existing therapies, making the...
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Zebrafish: A Versatile Animal Model to Study Tumorigenesis Process and Effective Preclinical Drug Screening for Human Cancer Research
Animal model systems are very important for preclinical evaluation of drugs and also to understand underlined pathophysiology and cellular cross...
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Patient-derived tumor models: a suitable tool for preclinical studies on esophageal cancer
Esophageal cancer (EC) is the tenth most common cancer worldwide and has high morbidity and mortality. Its main subtypes include esophageal squamous...
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Resurgence of syphilis: focusing on emerging clinical strategies and preclinical models
Syphilis, a sexually transmitted disease (STD) caused by Treponema pallidum ( T. pallidum ), has had a worldwide resurgence in recent years and remains...
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Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly,...
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Role of Modeling and Simulation in Preclinical and Clinical Long-Acting Injectable Drug Development
Innovations in the field of long-acting injectable drug development are increasingly being reported. More advanced in vitro and in vivo ...
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Available Preclinical Tools for Neuroblastoma
Neuroblastoma is the most predominant and deadly cancer in infants and in young children and contributes significantly to childhood cancer deaths....
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Harnessing preclinical models for the interrogation of ovarian cancer
Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding...
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Preclinical Models of Cardiac Disease: A Comprehensive Overview for Clinical Scientists
For recent decades, cardiac diseases have been the leading cause of death and morbidity worldwide. Despite significant achievements in their...
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Preclinical Studies on Mechanisms Underlying the Protective Effects of Propranolol in Traumatic Brain Injury: A Systematic Review
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity amongst trauma patients. Its treatment is focused on minimizing...
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The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
BackgroundAdvanced gastric cancer (GC) is a lethal malignancy, harboring recurrent alterations in cell cycle pathway, especially the...
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Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights
Arnicolide D, a potent sesquiterpene lactone from Centipeda minima , has emerged as a promising anticancer candidate, demonstrating significant...
