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Synaptogenesis and Synapse Elimination
Formation of excess synaptic connections at perinatal stage and subsequent elimination of redundant synapses and strengthening of the surviving ones...
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Synaptogenesis and Synapse Elimination in Develo** Cerebellum
Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex and play pivotal roles in the coordination, control, and learning of...
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Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development
During the nervous system development, synapses are initially overproduced. In the neuromuscular junction (NMJ) however, competition between several...
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Synapse Formation
The mammalian central nervous system consists of trillions of connections, called synapses, that are essential for human cognition, perception,...
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Synapse Formation
The mammalian central nervous system consists of trillions of connections, called synapses, that are essential for human cognition, perception,...
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mGluR1 Is a Molecular “Hub” for Synapse Elimination in the Develo** Cerebellum
Functional neural circuits of mature animals are formed by elimination of redundant synapses and strengthening of necessary connections during...
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Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, the mechanisms and...
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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease
Huntington’s disease (HD) is a devastating monogenic neurodegenerative disease characterized by early, selective pathology in the basal ganglia...
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Postnatal Development of Neuroimmune Responses
The early-life period represents a time of particular vulnerability to environmental and lifestyle stimuli that can shape our physiology long-term....
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As a Potential Therapeutic Target, C1q Induces Synapse Loss Via Inflammasome-activating Apoptotic and Mitochondria Impairment Mechanisms in Alzheimer’s Disease
C1q, the initiator of the classical pathway of the complement system, is activated during Alzheimer’s disease (AD) development and progression and is...
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C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity
Changes in neural activity induced by learning and novel environments have been reported to lead to the formation of new synapses in the adult brain....
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The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development
Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons...
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Synaptic pruning through glial synapse engulfment upon motor learning
Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and memory. Accumulating evidence suggests that glia...
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Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex
BackgroundDevelo** cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen...
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Glycogenolysis-Induced Astrocytic Ser**1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron
The bacterial pathogen, lipopolysaccharide (LPS), elicits microglial response and induces cytokine secretion that subsequently activates astrocytes....
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Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin
The mouse visual system serves as an accessible model to understand mammalian circuit wiring. Despite rich knowledge in retinal circuits, the...
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Imaging Synapse Formation and Remodeling In Vitro and In Vivo
Live-cell imaging technique contributes to the progress of modern life science, especially in the field of neurobiology. Molecular mechanism of...
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Synaptogenesis and Synapse Elimination
Formation of excess synaptic connections at perinatal stage and subsequent elimination of redundant synapses and strengthening of the surviving ones...