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Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program
Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program...
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SUFI: an automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and post-mortem human brain tissues
BackgroundMultispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring...
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Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations
The creation of interactive livestreaming post-mortem examination sessions for veterinary students is described, including the technological and...
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Post-mortem Magnetic Resonance Imaging of Degenerating and Reorganizing White Matter in Post-stroke Rodent Brain
Magnetic resonance imaging (MRI) allows noninvasive and non-destructive imaging of brain tissue. More specifically, the status of white matter fibers...
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New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue
Adult neurogenesis, the proliferation and integration of newly generated neurons, has been observed in the adult mammalian hippocampus of many...
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Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic...
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Developmental Origins of the Structural Defects Implicated in ASD: Insights from iPSC and Post-Mortem Studies
To reach a better understanding of the aetiology of autism spectrum disorders (ASD), different experimental tools must be leveraged to integrate data...
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Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples
The past decade has witnessed increasing evidence for a crucial role played by glial cells, notably astrocytes, in Alzheimer’s disease (AD). To...
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Ultrastructural characterization of dark microglia during aging in a mouse model of Alzheimer’s disease pathology and in human post-mortem brain samples
A diverse heterogeneity of microglial cells was previously described in Alzheimer’s disease (AD) pathology, including dark microglia, a state...
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Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia
BackgroundChronic neuroinflammation is one of the hallmarks of late-onset Alzheimer’s disease (AD) dementia pathogenesis. Carrying the apolipoprotein...
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Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h
Proteins can be successfully localized in post-mortem (PM) brain tissue sections if the time until PM tissue sampling is not too long. In this study,...
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Post-mortem computed tomography in forensic shooting distance estimation: a porcine cadaver study
ObjectivesGunshot wounds are frequently studied using computed tomography (CT) to examine tissue damage. In this study, we aimed to test the...
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Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study
BackgroundParkinson’s disease (PD) is characterized by intra-neuronal deposition of the protein α-synuclein (α-syn) and by deficiencies of the...
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Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data
Amyotrophic lateral sclerosis (ALS) displays considerable clinical and genetic heterogeneity. Machine learning approaches have previously been...
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Systematic post-mortem analysis of brain tissue from an HIV-1 subtype C viremic decedent revealed a paucity of infection and pathology
Whether the human brain is a robust reservoir for HIV-1 subtype C has yet to be established. We aimed to determine whether HIV-1 subtype C infection...
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Post-mortem diagnosis of imported malaria in France: a case report
BackgroundMalaria is a potentially lethal parasitic disease due to infection by Plasmodium parasites, transmitted by Anopheles mosquito vectors....
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Increased expression of pathological markers in Parkinson’s disease dementia post-mortem brains compared to dementia with Lewy bodies
BackgroundParkinson’s disease (PD) and dementia with Lewy bodies (DLB) are common age-related neurodegenerative diseases comprising Lewy body...
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Huntingtin HTT1a is generated in a CAG repeat-length-dependent manner in human tissues
BackgroundThe disease-causing mutation in Huntington disease (HD) is a CAG trinucleotide expansion in the huntingtin ( HTT ) gene. The mutated CAG...
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Epidemiological Survey on Post Mortem Coccidiosis in Broiler Chicken in Bejaia Province, Northern Algeria
AimThe epidemiological survey was carried out to determine the prevalence of eimeriosis in broiler chickens slaughtered depending the season, to...
