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Pain Disorders other than Migraine
Following injection into the muscle or skin, botulinum toxin blocks the release of pain transmitters and modulators and lead to reduction of pain...
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Based on Virtual Screening and Simulation Exploring the Mechanism of Plant-Derived Compounds with PINK1 to Postherpetic Neuralgia
Accumulating evidence strongly supports that PINK1 mutation can mediate mitochondrial autophagy dysfunction in dopaminergic neurons. This study was...
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Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Populations are ageing worldwide, with considerable time lived in ill-health, putting upwards pressure on healthcare budgets. Healthy ageing is...
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Genetically predicted immune cells mediate the association between gut microbiota and neuropathy pain
BackgroundPrevious observational studies have indicated a complex association between gut microbiota (GM) and neuropathic pain (NP). Nonetheless, the...
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Detection of human herpesviruses in cerebrospinal fluids collected from patients suspected of neuroinfectious diseases
The full spectrum of human herpesviruses (HHV)-associated neuroinfectious diseases in immunocompetent adults remains unclear. Hence, we sought to...
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Botulinum Toxin Therapy for Neuropathic Pain (NP)
Neuropathic pain (NP) arises from irritation or damage of nociceptive nerve fibers or nociceptive neurons. It is a common form of pain, often poorly...
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Subacute histopathological features in a case of varicella zoster virus myelitis and post-herpetic neuralgia
IntroductionPost-herpetic neuralgia is a crippling complication of varicella zoster virus (VZV) reactivation, also known as zoster disease. In rare...
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A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia
Reactivation of latent varicella-zoster virus (VZV) causes herpes zoster (HZ), which is commonly accompanied by acute pain and pruritus over the time...
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Botulinum Toxin in Dentistry and Treatment of Chronic Orofacial Pain
Chronic pain of the hard and soft tissues of the face and oral cavity is generally known as orofacial pain (OFP). OFP is a major issue in dentistry...
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Botulinum Toxin Therapy in Veterinary Medicine
Emerging literature supports that local injection of botulinum toxins can help local pain in animals. In dogs, botulinum toxin injections have been...
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Herpesviruses
The herpesviruses are large, enveloped DNA viruses, measuring 120–200 nm in diameter. They exhibit many common features, such as similar morphology...
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Cost and Insurance Issues in Botulinum Toxin Therapy
Botulinum toxin therapy is now an established mode of treatment for a large number of medical problems. It is FDA approved for treatment of migraine,...
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Effect of use of NSAIDs or steroids during the acute phase of pain on the incidence of chronic pain: a systematic review and meta-analysis of randomised trials
BackgroundThis study is the first to summarize the evidence on how the use of anti-inflammatory drugs during acute pain has an impact on the...
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HDAC inhibitors as a potential therapy for chemotherapy-induced neuropathic pain
Cancer, a chronic disease characterized by uncontrolled cell development, kills millions of people globally. The WHO reported over 10 million cancer...
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Emerging importance of satellite glia in nervous system function and dysfunction
Satellite glial cells (SGCs) closely envelop cell bodies of neurons in sensory, sympathetic and parasympathetic ganglia. This unique organization is...
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Evidence-Based Review of Current Botulinum Toxin Treatment Indications in Medicine
Botulinum neurotoxin (BoNT) has been increasingly used not only as a cosmetic drug but, more importantly, it has emerged as the most versatile...
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Acute herpes zoster and post herpetic neuralgia in primary care: a study of diagnosis, treatment and cost
Acute herpes zoster and its complication post herpetic neuralgia represent a significant challenge to primary care physicians in their care of an...
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Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of...
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Pharmaceutical perspective of neuropathic pain management for primary care providers
Neuropathic pain (NP) is a chronic condition that affects ~ 1% of the general population globally. Several conditions such as chronic diabetes,...
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Long-term use of intrathecal baclofen reduces neuropathic pain and its interference with general activity in spinal cord injury individuals
IntroductionLong-term analgesic effect of intrathecal baclofen was reported in individuals with spinal cord injury. We conducted a prospective study...
