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Disruption of Plasmodium falciparum histidine-rich protein 2 may affect haem metabolism in the blood stage
BackgroundHaem is a key metabolic factor in the life cycle of the malaria parasite. In the blood stage, the parasite acquires host haemoglobin to...
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Abnormal Porphyrin Metabolism in Autism Spectrum Disorder and Therapeutic Implications
Autism spectrum disorder (ASD) is a mosaic of neurodevelopmental conditions composed of early-onset social interaction and communication deficits,...
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The Immunogenetic Aspects of Photodynamic Therapy
Photodynamic therapy (PDT) has become the first-line treatment of actinic keratosis, superficial basal cell carcinoma, and squamous cell carcinoma in...
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FiTMuSiC: leveraging structural and (co)evolutionary data for protein fitness prediction
Systematically predicting the effects of mutations on protein fitness is essential for the understanding of genetic diseases. Indeed, predictions...
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Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran
In November 2019 givosiran became the second small interfering RNA (siRNA)-based drug to receive US Food and Drug Administration (FDA) approval, it...
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Why is Babesia not killed by artemisinin like Plasmodium?
Babesia spp. are intraerythrocytic apicomplexans that digest and utilize red blood cells in a similar way to intraerythrocytic Plasmodium spp., but...
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Oxidative-stress and long-term hepatotoxicity: comparative study in Upcyte human hepatocytes and hepaRG cells
Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions and a major cause of drug development failure and...
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Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
BackgroundAging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more...
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Therapeutic RNA-silencing oligonucleotides in metabolic diseases
Recent years have seen unprecedented activity in the development of RNA-silencing oligonucleotide therapeutics for metabolic diseases. Improved...
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Postmortem Clinical Testing
Testing of postmortem specimens for clinical analytes may be important in the determination of certain causes of death. Because of changes that occur...
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The Perspective of DMPK on Recombinant Adeno-Associated Virus-Based Gene Therapy: Past Learning, Current Support, and Future Contribution
Given the recent success of gene therapy modalities and the growing number of cell and gene-based therapies in clinical development across many...
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The expression of TLR2 and TLR4 in the kidneys and heart of mice infected with Acanthamoeba spp.
BackgroundAcanthamoeba spp. are cosmopolitan protozoans that cause infections in the brain, as well as extracerebral infections in the cornea, lungs...
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COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells
BackgroundGlioblastoma (GBM) is the deadliest and the most common primary brain tumor in adults. The invasiveness and proliferation of GBM cells can...
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Changes in the Expression of SNAP-25 Protein in the Brain of Juvenile Rats in Two Models of Autism
The results of genetic studies suggest a possible role for SNAP-25 polymorphism in the development of autism spectrum disorders (ASDs); however,...
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Many pitfalls in diagnosis of acute intermittent porphyria: a case report
BackgroundAcute intermittent porphyria is a rare autosomal dominant disorder caused by a deficiency of the enzyme, hydroxymethylbilane synthase....
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Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin
Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disease. The present study investigated the effects of 50 and 100 mg/kg...
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Severe hydroxymethylbilane synthase deficiency causes depression-like behavior and mitochondrial dysfunction in a mouse model of homozygous dominant acute intermittent porphyria
Acute intermittent porphyria (AIP) is an autosomal dominant inborn error of heme biosynthesis due to a pathogenic mutation in the Hmbs gene,...
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Vaccine Design, Nanoparticle Vaccines and Biomaterial Applications
Leishmaniasis is a neglected tropical disease subverting the immune system of the infected individual. Most of available treatment regimens are...