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Population pharmacokinetic modeling of levodropropizine: extended application to comparative analysis between commercial formulations and exploration of pharmacokinetic effects of diet
Levodropropizine, a nonopioid antitussive agent, is being increasingly used in clinical practice with the development of several formulations for...
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Clinical Pharmacokinetic Studies
Drug efficacy and response are a function of drug concentration over time. In clinical pharmacokinetic studies, aspects of drug absorption,...
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Compartmental Pharmacokinetic Models
Pharmacokinetic modeling is a tool that helps drug developers, clinicians, and health care professionals in general to understand and/or predict the...
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Population pharmacokinetic analyses of methotrexate in pediatric patients: a systematic review
Background and objectivesMethotrexate is widely utilized in the chemotherapy of malignant tumors and autoimmune diseases in the pediatric population,...
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Population Pharmacokinetic Analysis for Model-Based Therapeutic Drug Monitoring of Tacrolimus in Chinese Han Heart Transplant Patients
Background and ObjectiveTacrolimus has become the first-line immunosuppressant for preventing rejection after heart transplantation. The present...
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External Evaluation of Population Pharmacokinetic Models of Piperacillin in Preterm and Term Patients from Neonatal Intensive Care
Background and ObjectivesPiperacillin/tazobactam is extensively used off-label to treat late-onset neonatal sepsis, but safety and pharmacokinetic...
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External validation of population pharmacokinetic models of tacrolimus in Thai adult liver transplant recipients
ObjectiveSeveral population pharmacokinetic models of tacrolimus in liver transplant patients were built, and their predictability was evaluated in...
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Population pharmacokinetic analysis of lopinavir in HIV negative individuals exposed to SARS-CoV-2: a COPEP (COronavirus Post-Exposure Prophylaxis) sub-study
BackgroundLopinavir/ritonavir (LPV/r) is a drug traditionally used for the treatment of HIV that has been repurposed as a potential post-exposure...
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Population Pharmacokinetic Analysis of Vancomycin in Patients with Solid or Hematological Malignancy in Relation to the Quick Sequential Organ Failure Assessment Scores
Background and ObjectiveIt remains unclear whether sepsis in patients with malignancy interferes with the predictive performance of the...
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Population Pharmacokinetic Modeling and Dose Optimization of Acetaminophen and its Metabolites Following Intravenous Infusion in Critically ill Adults
Background and ObjectiveAcetaminophen (paracetamol) is a ubiquitously administered drug in critically ill patients. Considering the dearth of...
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External validation of population pharmacokinetic models of vancomycin in postoperative neurosurgical patients
ObjectiveVancomycin is commonly used in the prevention and treatment of intracranial infections in postoperative neurosurgical patients with narrow...
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Population Pharmacokinetic–Pharmacodynamic Modeling and Probability of Target Attainment Analysis of Rocuronium and Sugammadex in Children Undergoing Surgery
Background and ObjectivesProbability of target attainment (PTA) curves are commonly used to support dose recommendations of antibiotics for different...
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Population pharmacokinetic analyses of tacrolimus in non-transplant patients: a systematic review
Background and objectivesTacrolimus (TAC) has been increasingly used in patients with non-transplant settings. Because of its large between-subject...
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Integrated Population Pharmacokinetic Analysis of Ustekinumab Across Multiple Immune-Mediated Inflammatory Disease Populations and Healthy Subjects
Background and ObjectivesUstekinumab has been approved for the treatment of patients with plaque psoriasis (PSO), psoriatic arthritis (PSA), Crohn’s...
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Population pharmacokinetic, pharmacodynamic and efficacy modeling of SB12 (proposed eculizumab biosimilar) and reference eculizumab
PurposeTo describe, compare similarity of pharmacokinetic (PK), pharmacodynamic (PD) and efficacy of SB12 and reference eculizumab (ECU) and find...
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Does Sample Size, Sampling Strategy, or Handling of Concentrations Below the Lower Limit of Quantification Matter When Externally Evaluating Population Pharmacokinetic Models?
Background and ObjectivesPrecision dosing requires selecting the appropriate population pharmacokinetic model, which can be assessed through external...
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Population pharmacokinetic and pharmacodynamic analysis of rivaroxaban in Chinese patients with non-valvular atrial fibrillation
Rivaroxaban, a direct factor Xa inhibitor, is widely used for stroke prevention in patients with non-valvular atrial fibrillation (NVAF). The aim of...
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Estimation of linezolid exposure in patients with hepatic impairment using machine learning based on a population pharmacokinetic model
PurposeTo investigate the pharmacokinetic changes of linezolid in patients with hepatic impairment and to explore a method to predict linezolid...
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Population Pharmacokinetic and Pharmacodynamic Modeling of Fesoterodine in Pediatric Patients with Neurogenic Detrusor Overactivity
Background and ObjectiveFesoterodine is a muscarinic receptor antagonist approved for the treatment of overactive bladder (OAB) in adults and...
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A Hybrid Algorithm Combining Population Pharmacokinetic and Machine Learning for Isavuconazole Exposure Prediction
ObjectivesMaximum a posteriori Bayesian estimation (MAP-BE) based on a limited sampling strategy and a population pharmacokinetic (POPPK) model is...
