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Systematic review and pooled analysis of the impact of treatment-induced lymphopenia on survival of glioblastoma patients
Purpose/objective(s)Treatment related lymphopenia is a known toxicity for glioblastoma (GBM) patients and several single-institution studies have...
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Trilaciclib dosage in Chinese patients with extensive-stage small cell lung cancer: a pooled pharmacometrics analysis
This study aimed to analyze potential ethnic disparities in the dose–exposure–response relationships of trilaciclib, a first-in-class intravenous...
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Genomic profiling of small bowel adenocarcinoma: a pooled analysis from 3 databases
BackgroundSmall bowel adenocarcinoma is a rare disease. The genomic profiling tumours according to clinical characteristics and its impact on the...
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Implementation of pooled saliva tests for universal screening of cCMV infection
Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to neurodevelopmental disabilities. Universal newborn infant...
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Pooled prevalence and genetic diversity of norovirus in Africa: a systematic review and meta-analysis
BackgroundNoroviruses are the leading cause of acute gastroenteritis in all age groups globally. The problem is magnified in develo** countries...
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Evaluation of the pooled sample method in Infinium MethylationEPIC BeadChip array by comparison with individual samples
BackgroundThe pooled sample method is used in epigenomic research and expression analysis and is a cost-effective screening approach for small...
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Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis
BackgroundEthiopia is among the highly HIV-affected countries, with reported 12,000 and 12,000 AIDS-related deaths and incidents as per reports from...
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Interrogating breast cancer heterogeneity using single and pooled circulating tumor cell analysis
Single cell technologies allow the interrogation of tumor heterogeneity, providing insights into tumor evolution and treatment resistance. To better...
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Long-term air pollution exposure and malignant intracranial tumours of the central nervous system: a pooled analysis of six European cohorts
BackgroundRisk factors for malignant tumours of the central nervous system (CNS) are largely unknown.
MethodsWe pooled six European cohorts ( N = 302...
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A pooled analysis of outcomes according to cytogenetic abnormalities in patients receiving ixazomib- vs placebo-based therapy for multiple myeloma
Some cytogenetic abnormalities (CAs) are associated with poorer prognosis in multiple myeloma (MM); proteasome inhibitors appear to benefit patients...
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Dapagliflozin across the range of ejection fraction in patients with heart failure: a patient-level, pooled meta-analysis of DAPA-HF and DELIVER
Whether the sodium–glucose cotransporter 2 inhibitor dapagliflozin reduces the risk of a range of morbidity and mortality outcomes in patients with...
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Survival benefit and biomarker analysis of pyrotinib or pyrotinib plus capecitabine for patients with HER2-positive metastatic breast cancer: a pooled analysis of two phase I studies
BackgroundPyrotinib, a novel irreversible tyrosine kinase inhibitor (TKI), has demonstrated promising antitumor activity to improve the overall...
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Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies
BackgroundDNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in...
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Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium
BackgroundEvidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and...
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Impact of baseline body composition on prognostic outcomes in urological malignancies treated with immunotherapy: a pooled analysis of 10 retrospective studies
ObjectiveNumerous epidemiological investigations have explored the impact of body composition on the effectiveness of immune checkpoint inhibitors...
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Anthropometric traits and risk of multiple myeloma: a pooled prospective analysis
BackgroundObesity is a risk factor for multiple myeloma (MM), yet results of prior studies have been mixed regarding the importance of early and/or...
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Pathological regression of primary tumour and metastatic lymph nodes following chemotherapy in resectable OG cancer: pooled analysis of two trials
BackgroundNo definitive largescale data exist evaluating the role of pathologically defined regression changes within the primary tumour and lymph...
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Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials
BackgroundObesity is a major health concern for breast cancer survivors, being associated with high recurrence and reduced efficacy during cancer...
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Lower Limbs are the Most Difficult-to-Treat Body Region of Patients with Psoriasis: Pooled Analysis of CLEAR and CLARITY Studies of Secukinumab Versus Ustekinumab by Body Region
BackgroundThe impact of psoriasis, response to treatment, and patients’ perceptions of treatment satisfaction vary by body area.
Objectives ...
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A pooled case-only analysis of obesity and breast cancer subtype among Black women in the southeastern United States
PurposeTo evaluate the association between obesity and the relative prevalence of tumor subtypes among Black women with breast cancer (BC).
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