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Harnessing clonal gametes in hybrid crops to engineer polyploid genomes
Heterosis boosts crop yield; however, harnessing additional progressive heterosis in polyploids is challenging for breeders. We bioengineered a...
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Cytogeography of the Polyploid Complex Bassia prostrata s. l. (Chenopodiaceae) Based on Genome Size Analysis and PCR-RFLP cpDNA
AbstractThe cytogeography of the polyploid complex Bassia prostrata s. l. was studied by flow cytometry (FCM) on material from 39 populations in...
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Polyploid giant cancer cells, cytokines and cytomegalovirus in breast cancer progression
BackgroundBreast cancer is the most common cancer among women. Accumulated evidence over the past decades indicates a very high prevalence of human...
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The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells
Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some...
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Generation of Polyploid Giant Cancer Cells (PGCCs) from Hey Ovarian Cancer Cells and Analysis of Embryonic Properties
Polyploid giant cancer cells (PGCCs) play a fundamental role in tumor initiation, dormancy, drug resistance, and metastasis, although the detailed...
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Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells
BackgroundPolyploid giant cancer cells (PGCCs), a specific type of cancer stem cells (CSCs), can be induced by hypoxic microenvironments, chemical...
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Single-Cell MTT: A Simple and Sensitive Assay for Determining the Viability and Metabolic Activity of Polyploid Giant Cancer Cells (PGCCs)
Solid tumors and tumor-derived cell lines commonly contain highly enlarged (giant) cancer cells that enter a state of transient dormancy (active...
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Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)
BackgroundGenomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells...
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Histological diagnosis of polyploidy discriminates an aggressive subset of hepatocellular carcinomas with poor prognosis
BackgroundAlthough genome duplication, or polyploidization, is believed to drive cancer evolution and affect tumor features, its significance in...
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Simple Sequence Repeat and S-Locus Genoty** to Assist the Genetic Characterization and Breeding of Polyploid Prunus Species, P. spinosa and P. domestica subsp. insititia
Polyploid Prunus spinosa (2 n = 4 ×) and P. domestica subsp. insititia (2 n = 6 ×) represent enormous genetic potential in Central Europe, which can be...
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Eupolyploidy As a Mode in Plant Speciation
AbstractWhen discussing phenomena of whole genome duplication, the terms “neopolyploid,” “mesopolyploid,” and “paleopolyploid” are used in their...
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Genome assemblies of 11 bamboo species highlight diversification induced by dynamic subgenome dominance
Polyploidy (genome duplication) is a pivotal force in evolution. However, the interactions between parental genomes in a polyploid nucleus,...
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Assembly of whole-chromosome pseudomolecules for polyploid plant genomes using outbred map** populations
Despite advances in sequencing technologies, assembly of complex plant genomes remains elusive due to polyploidy and high repeat content. Here we...
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Population Genetics of Polyploid Complex Psidium cattleyanum Sabine (Myrtaceae): Preliminary Analyses Based on New Species-Specific Microsatellite Loci and Extension to Other Species of the Genus
Polyploidy is a phenomenon that alters the genetic diversity of populations and has been reported as one of the most important evolutionary forces...
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CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines
Malignant features such as the acquisition of metastatic ability, stemness of cells, and therapeutic resistance of cancer cells are associated with...
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Phenomenon of Multiple Mutations in the 35S rRNA Genes of the C Subgenome of Polyploid Avena L.
AbstractUsing sequence-tagged DNA sequencing on the Roche 454 platform, we studied intragenomic polymorphism of one of the 35S rRNA regions (18S rDNA...
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Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells
BackgroundOur previous studies have confirmed that cobalt chloride (CoCl 2 ) can induce the formation of polyploid giant cancer cells (PGCCs), which...
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Ploidy Modification for Plant Breeding Using In Vitro Organogenesis: A Case in Eggplant
The use of antimitotic agents such as colchicine has been common to obtain polyploid organisms. However, this approach entails certain problems, from...