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Showing 1-20 of 8,840 results

  1. Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation

    The most common inherited cause of two genetically and clinico-pathologically overlap** neurodegenerative diseases, amyotrophic lateral sclerosis...

    Feilin Liu, Dmytro Morderer, ... Wilfried Rossoll in Acta Neuropathologica Communications
    Article Open access 14 February 2022

  2. C9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD

    Hexanucleotide repeat expansions (HREs) in the chromosome 9 open reading frame 72 ( C9orf72 ) gene are the most frequent genetic cause of amyotrophic...

    Jessica Sultana, Audrey M. G. Ragagnin, ... Julie D. Atkin in Molecular Neurobiology
    Article Open access 09 May 2024

  3. Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

    A C9orf72 repeat expansion is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis. One of the suggested...

    Annelies Quaegebeur, Idoia Glaria, ... Adrian M. Isaacs in Acta Neuropathologica Communications
    Article Open access 09 November 2020

  4. Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

    Amyotrophic lateral sclerosis overlap** with frontotemporal dementia (ALS/FTD) is a fatal and currently untreatable disease characterized by rapid...

    Kornélia Szebényi, Léa M. D. Wenger, ... András Lakatos in Nature Neuroscience
    Article Open access 21 October 2021

  5. HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

    Human homologue of yeast UV excision repair protein Rad23b (HR23B) inclusions are found in a number of neurodegenerative diseases, including...

    Frederike W. Riemslagh, Hannes Lans, ... Rob Willemsen in Acta Neuropathologica Communications
    Article Open access 13 March 2019

  6. Functionalized Nanoparticles for Cancer Therapy

    Chemotherapy is a standard cancer therapy but it has adverse effects because it sometimes fails to deliver therapeutic drugs to tumour cells in safe...
    Md. Meraj Ansari, Zamurrad Nayab, ... Rehan Khan in Personalized and Precision Nanomedicine for Cancer Treatment
    Chapter 2024

  7. Circadian sleep/wake-associated cells show dipeptide repeat protein aggregates in C9orf72-related ALS and FTLD cases

    Motor-, behavior- and/or cognition-related symptoms are key hallmarks in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar...

    Lieselot Dedeene, Evelien Van Schoor, ... Dietmar Rudolf Thal in Acta Neuropathologica Communications
    Article Open access 02 December 2019

  9. Polymeric Micelles in the Delivery of Proteins

    Polymeric micelles (PM) developed in solution by self-assembling of amphiphilic polymers and represents an advanced tool to overcome several issues...
    Sumel Ashique, Ashish Garg, ... Neeraj Mishra in Polymeric Micelles: Principles, Perspectives and Practices
    Chapter 2023

  10. Translation dysregulation in neurodegenerative diseases: a focus on ALS

    RNA translation is tightly controlled in eukaryotic cells to regulate gene expression and maintain proteome homeostasis. RNA binding proteins,...

    Shaopeng Wang, Shuying Sun in Molecular Neurodegeneration
    Article Open access 25 August 2023

  11. Tumor Microenvironment and Tumor-Targeted Therapy

    Cancer tissue or cancer cells do not exist in isolation, but start life within the microenvironment called tumor microenvironment (TME). The...
    Hongxia Duan, Wei Huang in Handbook of Cancer and Immunology
    Living reference work entry 2023

  12. Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors

    Multilayer microcapsules fabricated via the layer-by-layer (LbL) assembly method with tailored structures and functionalities are promising...
    Weijun Tong, Changyou Gao in Polymeric Biomaterials for Tissue Regeneration
    Chapter 2023

  14. Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies

    Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in...

    Mojgan Sheikhi, Nasrin Nemayandeh, Mehrnoosh Shirangi in Pharmaceutical Research
    Article 19 March 2024

  15. Models of Neurodegenerative Diseases

    Neurodegenerative diseases comprise a wide range of age-related conditions, characterized by the loss of neurons leading to a progressive decline in...
    Niran Maharjan, Smita Saxena in Neurogenetics
    Chapter 2023

  16. Polymers for Pharmaceutical 3D Printing: Printability and Critical Insight into Material Properties

    This chapter offers a focused exploration of the pivotal role of polymers in pharmaceutical 3D printing, delving into both their printability and...
    Christian Muehlenfeld, Patrick Duffy, ... Thomas Durig in 3D Printing
    Chapter 2024

  17. Repeat length of C9orf72-associated glycine–alanine polypeptides affects their toxicity

    G 4 C 2 hexanucleotide repeat expansions in a non-coding region of the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis...

    Javier Morón-Oset, Lilly Katharina Sophie Fischer, ... Linda Partridge in Acta Neuropathologica Communications
    Article Open access 29 August 2023

  18. Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

    Repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we show...

    Yini Li, **aoyang Dou, ... Shuying Sun in Nature Neuroscience
    Article 26 June 2023

  19. Dendrimers-Mediated Delivery of Phytoconstituents

    The potential for dendrimers, highly branching three-dimensional macromolecules, to function as drug delivery vehicles has been extensively...
    Divya Bharti Rai, Kanakraju Medicherla, ... Hitesh Kulhari in Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals
    Chapter 2024

  20. Choice of Enzyme Immobilization Matrices Used in Biosensor for Healthcare Applications

    Immobilization of enzymes is a process of obtaining stable, active, and reusable enzymes used in industrial and medical fields for biosensor...
    Sanjeev Bhandari, Manashjit Gogoi, Mrityunjoy Mahato in Enzyme-based Biosensors: Recent Advances and Applications in Healthcare
    Chapter 2023
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