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Platelet-Derived Extracellular Vesicles in Disease Therapy
Platelets are vesicle-related cells in the blood. Indeed, platelets are regarded as vesicles themselves because they do not contain nuclei, and they...
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Improving Platelet Apheresis Hardware
The efficiency of preparing donor platelet concentrates using the MCS+ apparatus (Haemonetics, USA) using the Leukodepleted Platelet (LDP) protocol...
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Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrates (PCs) collected from...
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An overview of qualitative and quantitative platelet abnormalities in schistosomiasis
Schistosomiasis is a neglected tropical disease referring to the infection with blood parasitic trematodes of the genus Schistosoma . It impacts...
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The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis
BackgroundPodoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate...
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EGFR of platelet regulates macrophage activation and bacterial phagocytosis function
BackgroundBeyond their crucial role in hemostasis, platelets possess the ability to regulate inflammation and combat infections through various...
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The interaction of platelet-related factors with tumor cells promotes tumor metastasis
Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by...
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Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells
Rare multipotent stem cells replenish millions of blood cells per second through a time-consuming process, passing through multiple stages of...
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Mean platelet volume/platelet count ratio in combination with tumor markers in colorectal cancer: a retrospective clinical study
BackgroundMean platelet volume (MPV) is a marker of platelet activation, which is usually negatively correlated with platelet count (PC). The ratio...
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Differential inhibition of platelet function by cilostazol in combination with clopidogrel
PurposeTo assess the antiplatelet effect of cilostazol clinically, we compared the effects of cilostazol in combination with clopidogrel on various...
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Non-clinical investigations about cytotoxic and anti-platelet activities of gamma-terpinene
Gamma-terpinene (γ-TPN) is a cyclohexane monoterpene isolated from plant essential oils, such as tea tree ( Melaleuca alternifolia ), oregano ( Origanum...
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Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity
IntroductionAcetaminophen (APAP) toxicity remains a significant cause of adult and pediatric liver failure in North America and Europe. Previous...
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Regulation of Human Platelet Adhesion with Ascorbic Acid
Morphofunctional characteristics of human platelets in the presence of 0.1-5 mM ascorbic acid were studied. The platelet ability to form lamellae and...
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Analysis and Regulatory Mechanisms of Platelet-Related Genes in Patients with Ischemic Stroke
It was found that ischemic stroke (IS) was associated with abnormal platelet activity and thrombosis. However, the potential significance of...
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Assessment of Platelet Function by Automated Light Transmission Aggregometry
Light transmission aggregometry (LTA) has long been the historical “gold standard” of platelet function testing and is typically performed in...
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Tumor educated platelet: the novel BioSource for cancer detection
Platelets, involved in the whole process of tumorigenesis and development, constantly absorb and enrich tumor-specific substances in the circulation...
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Revealing platelet-related subtypes and prognostic signature in pancreatic adenocarcinoma
BackgroundPancreatic adenocarcinoma (PDAC) is a malignant tumor with high heterogeneity and poor prognosis. In this study, we sought to identify the...
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Synthesis and effects of ginkgolides and ginkgolide B derivatives on platelet activating factor induced platelet aggregation in rabbits
The natural product Ginkgolide B was used as a raw material and modified by etherification on C10–OH to obtain 10 derivatives ( 1 to 10 ), which were...
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Growth-Stimulating Effect of Platelet Preparations Obtained by Different Methods on Human Fibroblast Culture
We studied the growth-stimulating effect of platelet-based preparations obtained by different methods on cultured human fibroblasts M-22. Platelet...
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Assessment of Platelet Function by High-Throughput Screening Light Transmission Aggregometry: Optimul Assay
Platelet function testing is critical in the diagnosis of bleeding disorders and allows monitoring of antiplatelet therapy. The gold standard assay,...