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Characterization of a nuclear transport factor 2-like domain-containing protein in Plasmodium berghei
BackgroundPlasmodium lacks an mRNA export receptor ortholog, such as yeast Mex67. Yeast Mex67 contains a nuclear transport factor 2 (NTF2)-like...
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A heparin-binding protein of Plasmodium berghei is associated with merozoite invasion of erythrocytes
BackgroundMalaria caused by Plasmodium species is a prominent public health concern worldwide, and the infection of a malarial parasite is...
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Comparative analyses of functional antibody-mediated inhibition with anti-circumsporozoite monoclonal antibodies against transgenic Plasmodium berghei
BackgroundAcquired functional inhibitory antibodies are one of several humoral immune mechanisms used to neutralize foreign pathogens. In vitro...
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Antiplasmodial Activity of β-Ionone and the Effect of the Compound on Amelioration of Anaemia and Oxidative Organ Damage in Mice Infected with Plasmodium berghei
IntroductionOwing to evolution of parasite strains that are resistant to existing antimalarial drugs, research for novel antimalarial medicines is...
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Vitamin C-rich juice co-administration with artemether-lumefantrine ameliorates oxido-inflammatory responses in Plasmodium berghei-infected mice
This study investigated the effects of co-administration of a commercial juice rich in vitamin C (Vit C) on the antimalarial efficacy of...
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A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei
BackgroundSafe and effective vaccines are crucial for the control and eventual elimination of malaria. Novel approaches to optimize and improve...
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Plasmodium berghei Brca2 is required for normal development and differentiation in mice and mosquitoes
BackgroundMalaria is a major global parasitic disease caused by species of the genus Plasmodium . Zygotes of Plasmodium spp. undergo meiosis and...
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The C-terminal region of the Plasmodium berghei gamete surface 184-kDa protein Pb184 contributes to fertilization and male gamete binding to the residual body
BackgroundMalaria, a global health concern, is caused by parasites of the Plasmodium genus, which undergo gametogenesis in the midgut of mosquitoes...
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High-carbohydrate diet lacked the potential to ameliorate parasitemia and oxidative stress in mice infected with Plasmodium berghei
The search for a novel prophylactic agent against malaria is on the rise due to the negative socio-economic impact of the disease in tropical and...
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Let it glow: genetically encoded fluorescent reporters in Plasmodium
The use of fluorescent proteins (FPs) in Plasmodium parasites has been key to understand the biology of this obligate intracellular protozoon. FPs...
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A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria
Two malaria parasite species, Plasmodium falciparum ( Pf ) and P. vivax ( Pv ) are responsible for most of the disease burden caused by malaria. Vaccine...
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Influenza virus-like particle vaccine containing both apical membrane antigen 1 and microneme-associated antigen proteins of Plasmodium berghei confers protection in mice
BackgroundApical membrane antigen 1 (AMA1) and microneme-associated antigen (MIC) of Plasmodium parasites are important factors involved in host...
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Correlative light-electron microscopy methods to characterize the ultrastructural features of the replicative and dormant liver stages of Plasmodium parasites
BackgroundThe infection of the liver by Plasmodium parasites is an obligatory step leading to malaria disease. Following hepatocyte invasion,...
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Effect of α-Tocopheryloxy Acetic Acid on the Infection of Mice with Plasmodium berghei ANKA In Vivo and Humans with P. falciparum In Vitro
PurposeMalarial parasites are susceptible to oxidative stress. The effects of α-tocopheryloxy acetic acid (α-TEA), a vitamin E analog, on infection...
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A conserved protein of Babesia microti elicits partial protection against Babesia and Plasmodium infection
BackgroundThe protozoan parasite Babesia microti that causes the zoonotic disease babesiosis resides in the erythrocytes of its mammalian host...
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Conditional Gene Deletion in Mammalian and Mosquito Stages of Plasmodium berghei Using Dimerizable Cre Recombinase
Genome editing in the malaria parasite Plasmodium relies on homologous recombination and requires parasite transfection in asexual blood stages....
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Testing a non-destructive assay to track Plasmodium sporozoites in mosquitoes over time
BackgroundThe extrinsic incubation period (EIP), defined as the time it takes for malaria parasites in a mosquito to become infectious to a...
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Antiplasmodial Effect of Nano Dendrimer G2 Loaded with Chloroquine in Mice Infected with Plasmodium berghei
BackgroundMalaria is a parasitic lethal disease caused by Plasmodium protozoa. The resistance and drugs’ side effects have led to numerous...
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Development and optimizing a simple and cost-effective medium for in vitro culture of Plasmodium berghei-ANKA strain with conserving its infectivity in BALB/c mice
ObjectivesThe current culture system for P. berghei still requires modifications in consistency and long-term maintenance of parasites considering...
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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...