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Cryopreserved placental biopsies maintain mitochondrial activity for high-resolution respirometry
BackgroundHigh-resolution respirometry (HRR) of human biopsies can provide useful metabolic, diagnostic, and mechanistic insights for clinical...
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Two cases of placental trisomy 21 mosaicism causing false-negative NIPT results
BackgroundNon-invasive prenatal testing (NIPT) using cell-free DNA has been widely used for prenatal screening to detect the common fetal...
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Dissociation of Placental Tissues for Single-Cell Techniques
The dissociation of whole tissue into single-cell suspensions is a critical step for techniques focused on profiling of individual cells. Here, we...
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The Placental Function Beyond Pregnancy: Insights from Latin America
Currently, more than 100,000 papers had been published studying the placenta in both physiological and pathological contexts. However, relevant...
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Placental neutrophil reverse trans-migration and maternal serum neutrophil extracellular trap expression in HIV infection co-morbid pre-eclampsia in women of African ancestry
Neutrophil extracellular traps (NETs) and placental neutrophil reverse transmigration (r-TM) are implicated in the pathogenesis of pre-eclampsia...
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Multi-scale Modelling of Shear Stress on the Syncytiotrophoblast: Could Maternal Blood Flow Impact Placental Function Across Gestation?
The placenta is a critical fetal exchange organ, with a complex branching tree-like structure. Its surface is covered by a single multinucleated...
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Alternative Splicing Landscape of Placental Decidual Cells during Physiological Pregnancy
AbstractAlternative splicing (AS) of RNA is a key step in the post-transcriptional regulation of gene expression. It provides transcriptional...
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Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation
BackgroundGlucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of...
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Placental growth factor promotes neural invasion and predicts disease prognosis in resectable pancreatic cancer
BackgroundSurgery represents the only curative treatment option for pancreatic ductal adenocarcinoma (PDAC), but recurrence in more than 85% of...
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Placental 13C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight
BackgroundFetal docosahexaenoic acid (DHA) supply relies on preferential transplacental transfer, which is regulated by placental DHA lipid...
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Identification and characterisation of maternal perivascular SUSD2+ placental mesenchymal stem/stromal cells
Mesenchymal stem cells (MSCs) that meet the International Society for Cellular Therapy (ISCT) criteria are obtained from placental tissue by plastic...
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Circulating Non-coding RNAs and Exosomes: Liquid Biopsies for Monitoring Preeclampsia
Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the...
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Gravidity-dependent associations between interferon response and birth weight in placental malaria
BackgroundMaternal malarial infection leads to poor perinatal outcomes, including low birth weight from preterm delivery and/or fetal growth...
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Isolation of total DNA from Placenta Samples, both Fresh and following Formalin and Paraffin Treatment
The isolation of DNA from placental tissue suspected of infection is an important tool for identifying microorganisms such as bacteria, fungi, and...
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Determinants of placental iodine concentrations in a mild-to-moderate iodine-deficient population: an ENVIRONAGE cohort study
BackgroundIodine is an essential trace element for the production of thyroid hormones, and plays a key role during the gestational period for optimal...
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The impact of gravidity, symptomatology and timing of infection on placental malaria
BackgroundPlacental malaria is associated with increased risk of adverse perinatal outcomes. While primigravidity has been reported as a risk factor...
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Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation
BackgroundPrenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the...
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Labour and premature delivery differentially affect the expression of the endocannabinoid system in the human placenta
Plasma concentrations of N -arachidonyletholamine (AEA), N -oleoylethanolamide (OEA) and N -palmitoylethanolamide (PEA) increase at term and can predict...
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A placental trisomy 2 detected by NIPT evolved in a fetal small Supernumerary Marker Chromosome (sSMC)
BackgroundNon-invasive prenatal testing (NIPT) is a rapidly develo** and widely used method in the prenatal screening. Recently, the widespread use...
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Rare autosomal trisomies detected by non-invasive prenatal testing: an overview of current knowledge
Non-invasive prenatal testing has been introduced for the detection of Trisomy 13, 18, and 21. Using genome-wide screening also other “rare”...
