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Missing pieces of the pituitary puzzle: participation of extra-adenohypophyseal placode-lineage cells in the adult pituitary gland
The pituitary gland is a major endocrine tissue composing of two distinct entities, the adenohypophysis (anterior pituitary, cranial placode origin)...
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Comparison of central diabetes insipidus (antidiuretic hormone deficiency) and stalk effect in patients with adamantinomatous and papillary craniopharyngioma
Craniopharyngioma (CP), a rare benign intracranial tumor, is still a major clinical challenge. There are two major histologic phenotypes: papillary...
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Benign and Malignant Tumors of the Pituitary Gland
Pituitary glandPituitary gland tumors represent approximately 10–15% of all brain tumorsBrain tumor and the most common neoplasmsNeoplasm of the...
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MRI atlas of the pituitary gland in young female adults
The probabilistic topography and inter-individual variability of the pituitary gland (PG) remain undetermined. The absence of a standardized...
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Knockout mice with pituitary malformations help identify human cases of hypopituitarism
BackgroundCongenital hypopituitarism (CH) and its associated syndromes, septo-optic dysplasia (SOD) and holoprosencephaly (HPE), are midline defects...
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Structure–function relationship of the pituitary gland in anorexia nervosa and intense physical activity
Patients with Anorexia Nervosa (AN) and athletes share intense physical activity and pituitary hormonal disturbances related to absolute (AN) or...
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New insights into the role and origin of pituitary S100β-positive cells
In the anterior pituitary, S100β protein (S100β) has been assumed to be a marker of folliculo-stellate cells, which are one of the...
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Brain Control over Pituitary Gland Hormones
Endocrine organs release their products, hormones, into peripheral blood to travel great distances to exert their biological effects. The brain is...
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Regulation of the Hypothalamo-Pituitary-Adrenal Axis in Pregnancy and Lactation
Physiological and behavioural responses to stress are critical to ensure individual survival in all species. This is even more important when the...
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Statins may Decrease Aneurysm wall Enhancement of Unruptured Fusiform Intracranial Aneurysms: A high-resolution 3T MRI Study
Inflammation plays an integral role in the formation, growth, and progression to rupture of unruptured intracranial aneurysms. Aneurysm wall...
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The multiciliated cells in Rathke’s cleft express CYP26A1 and respond to retinoic acid in the pituitary
The adenohypophysis consists of the anterior and intermediate lobes (AL and IL). The marginal cell layer (MCL), including the ventral region of the...
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Robot-Assisted Pituitary Surgery
The transsphenoidal approach represents the gold standard for surgical excision of pituitary tumors. Over the last few decades the endoscopic...
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Brain Control over Pituitary Gland Hormones
Endocrine organs release their products, hormones, into peripheral blood to travel great distances to exert their biological effects. The brain is...
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Lectures 9 and 10: Endocrine System & Hormones
The Endocrine System consists the following organs: Hypothalamus, pituitary (anterior & posterior parts), pineal, thyroid, 4 parathyroids, thymus,...
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The Pituitary Tumors and Their Tumor-Specific Microenvironment
Pituitary tumors develop within a macroenvironment and microenvironment that favor their overall survival. Given the pituitary gland’s unique...
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Lactation and the Control of the Prolactin Secretion
Prolactin is a polypeptide hormone secreted from the lactotrophs in the anterior pituitary gland. It is recognized as a pleiotropic hormone with...
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Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser
Thus far, attempts to develop drugs that target corticotropin-releasing hormone receptor 1 (CRF 1 R), a drug target in stress-related therapy, have...
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Novel Isoforms of Adhesion G Protein-Coupled Receptor B1 (ADGRB1/BAI1) Generated from an Alternative Promoter in Intron 17
Brain-specific angiogenesis inhibitor 1 (BAI1) belongs to the adhesion G-protein-coupled receptors, which exhibit large multi-domain extracellular N...
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Sparing the hippocampus and the hypothalamic- pituitary region during whole brain radiotherapy: a volumetric modulated arc therapy planning study
BackgroundFeasibility testing of a simultaneous sparing approach of hippocampus, hypothalamus and pituitary gland in patients undergoing whole-brain...
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Craniopharyngioma in Pediatrics and Adults
Craniopharyngiomas are rare malignancies of dysembryogenic origin, involving the sellarSellar and parasellarParasellar areas. These low-grade,...