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Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients,...
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Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats
Mechanical sensing Piezo2 channel in primary sensory neurons has been shown contribute to mechanical allodynia in somatic chronic pain conditions....
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Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics
Unraveling the intricate relationship between mechanical factors and brain activity is a pivotal endeavor, yet the underlying mechanistic model of...
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Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy
Dry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely known pathomechanism. It is suggested to represent a...
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Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats
Mechanosensitive cation channels such as Piezo1 and Piezo2 are activated by mechanical force like a starched wall of the aorta while blood pressure...
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Profile of dorsal root ganglion neurons: study of oxytocin expression
Although dorsal root ganglion (DRG) neurons have been so far classified according to the difference in their fibers (Aβ, Aδ, and C), this...
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Hypergravity Increases the Number of Gene Transcripts of Mechanically Gated and Mechanosensitive Ion Channels in Rat Ventricular Cardiomyocytes
Since hypergravity changes the morphological and physiological properties of the heart, it was assumed that the expression of ion channels that...
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Piezo channels in the urinary system
The Piezo channel family, including Piezo1 and Piezo2, includes essential mechanosensitive transduction molecules in mammals. Functioning in the...
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The mechanosensory neurons of touch and their mechanisms of activation
Our sense of touch emerges from an array of mechanosensory structures residing within the fabric of our skin. These tactile end organ structures...
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Piezo1, the new actor in cell volume regulation
All animal cells control their volume through a complex set of mechanisms, both to counteract osmotic perturbations of the environment and to enable...
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Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
BackgroundAccumulating studies have shown that tumors are regulated by nerves, and there is abundant nerve infiltration in the tumor...
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Epithelial-Neuronal Communication in Visceral Pain
Visceral hypersensitivity and pain are common symptoms of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Pain results, at least...
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Novel mutations in TPM2 and PIEZO2 are responsible for distal arthrogryposis (DA) 2B and mild DA in two Chinese families
BackgroundDistal arthrogryposis (DA) is a group of clinically and genetically heterogeneous disorders that involve multiple congenital limb...
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Progress in Pathological and Therapeutic Research of HIV-Related Neuropathic Pain
HIV-related neuropathic pain (HRNP) is a neurodegeneration that gradually develops during the long-term course of acquired immune deficiency syndrome...
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Nobel somatosensations and pain
The Nobel prices 2021 for Physiology and Medicine have been awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for...
