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Physico-chemical Modifications of Magnesium and Alloys for Biomedical Applications
A unique combination of impressive biodegradability and biocompatibility makes magnesium (Mg) and its alloys a promising candidate in biomedical...
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Nanomedicines and nanocarriers in clinical trials: surfing through regulatory requirements and physico-chemical critical quality attributes
Elucidation of physical-chemical characteristics of investigational medicinal products should be established with suitable methodology....
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The Influence of Relative Humidity and Storage Conditions on the Physico-chemical Properties of Inhalation Grade Fine Lactose
Dry powder inhalers (DPIs) are favorable devices for the delivery of dry formulations to the lungs; still, they largely fail to deliver higher doses...
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Changes of physico-chemical properties of nano-biomaterials by digestion fluids affect the physiological properties of epithelial intestinal cells and barrier models
BackgroundThe widespread use of nano-biomaterials (NBMs) has increased the chance of human exposure. Although ingestion is one of the major routes of...
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One-Pot Synthesis of CdTe/ZnS Quantum Dots and their Physico-Chemical Characterization
A known property of quantum dots (QDs) is their characteristic luminescence, which would make it possible to detect different types of cancers after...
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Impact of Processing Methods on the Physico-chemical Properties of Posaconazole Amorphous Solid Dispersions
Background & PurposeDifferent methods have been exploited to generate amorphous solid dispersions (ASDs) of poorly water-soluble drugs. However, the...
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Influence of physico-chemical properties of two lipoxin emulsion-loaded hydrogels on pre-polarized macrophages: a comparative analysis
Inflammation, a crucial defense mechanism, must be rigorously regulated to prevent the onset of chronic inflammation and subsequent tissue damage....
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Using soil bacterial communities to predict physico-chemical variables and soil quality
BackgroundSoil ecosystems consist of complex interactions between biological communities and physico-chemical variables, all of which contribute to...
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Comparative study of cilnidipine loaded PLGA nanoparticles: process optimization by DoE, physico-chemical characterization and in vivo evaluation
Cilnidipine (CND) is known to have low oral bioavailability due to its poor aqueous solubility, low dissolution rate, and high gut wall metabolism....
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Synthesis of Novel [{(2-Amino-5-Nitro-N-[(E)-Thiophen-2-yl-Methylidene]Aniline-κ3N1:N4:S)(Sulphato-κ2O1:O3)}Zinc(II)] Complex with Physico-Chemical and Biological Perspective Exploration: A Combined Experimental and Computational Studies
A novel metal complex was synthesized using freshly prepared 2-Amino-5-nitro-N-[(E)-thiophen-2-yl-methylidene]aniline ligand with Zn (II) sulphate...
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Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure
IL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact...
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Anopheles larval habitats seasonality and environmental factors affecting larval abundance and distribution in Arjo-Didessa sugar cane plantation, Ethiopia
BackgroundWater resource development projects are essential for increasing agricultural productivity and ensuring food security. However, these...
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Pharmaceutics Informatics: Bio/Chemoinformatics in Drug Delivery
Whilst bioinformatics deals with the biological receptors and proteins (biological macromolecules) and their manipulation, the chemoinformatics is...
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A molecular docking study between heavy metals and hydrophilic Hsp70 protein to explore binding pockets
Microorganisms are abundant in whole biosphere and exert influential activities on numerous biological phenomena. The source of heavy metal...
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In Silico Study on the Contribution of the Follicular Route to Dermal Permeability of Small Molecules
PurposeThis study investigates in silico the contribution of the hair follicle to the overall dermal permeability of small molecules, as published...
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Classification, Synthesis and Application of Nanoparticles Against Infectious Diseases
Nowadays, resistant bacterial strains have become major threats to medical science, causing various infectious disease conditions against different...
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Polymeric Micelles: Principles, Perspectives and Practices
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the...
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Effect of Food Composition on the PK of Isoniazid Quantitatively Explained Using Physiologically Based Biopharmaceutics Modeling
This work shows the utilization of a physiologically based biopharmaceutics model (PBBM) to mechanistically explain the impact of diverse food types...
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In silico design of a novel peptide-based vaccine against the ubiquitous apicomplexan Toxoplasma gondii using surface antigens
Human toxoplasmosis is a global public health concern and a commercial vaccine is still lacking. The present in silico study was done to design a...
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In silico analysis of sporozoite surface antigen 1 of Theileria annulata (TaSPAG1) for multi-epitope vaccine design against theileriosis
Tropical theileriosis is a protozoan infection caused by Theileria annulata , which significantly affects cattle worldwide. This study was aimed to...
