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Li–Fraumeni syndrome in Tunisian carriers with different and rare tumor phenotype: genotype–phenotype correlation
BackgroundLi–Fraumeni syndrome (LFS) is a rare autosomal hereditary predisposition to multiples cancers, mainly affecting young individuals. It is...
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Effect of adjuvant radiotherapy on overall survival and breast cancer-specific survival of patients with malignant phyllodes tumor of the breast in different age groups: a retrospective observational study based on SEER
PurposeMalignant phyllodes tumor of the breast (MPTB) is a rare type of breast cancer, with an incidence of less than 1%. The value of adjuvant...
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Breast Cancer: Epidemiology, Types, Diagnosis, and Treatment
Breast cancer is a complex disease, and many aspects of this disease are under intensive research. Better treatment of breast cancer can only be...
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Targeting CRAF kinase in anti-cancer therapy: progress and opportunities
The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly dysregulated in human malignancies by processes driven by RAS or RAF ...
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Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis
BackgroundAs the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all...
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Feasibility study of dual parametric 2D histogram analysis of breast lesions with dynamic contrast-enhanced and diffusion-weighted MRI
BackgroundThis study aimed to investigate the diagnostic value of a dual-parametric 2D histogram classification method for breast lesions.
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Pharmacognostical Botany: Classification of Medicinal and Aromatic Plants (MAPs), Botanical Taxonomy, Morphology, and Anatomy of Drug Plants
Diverse plant species of the earth constitute the fundamental source of crude drugs and the diversified botanical species comprising of non-seed and...
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The off-label use of targeted therapies in sarcomas: the OUTC’S program
BackgroundFew targeted therapies (TTs) are registered for sarcoma treatment despite numerous phase II studies and yet there are potential treatment...
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The Non-Crosslinking Fixative RCL2®-CS100 is Compatible with Both Pathology Diagnosis and Molecular Analyses
Formalin is the key agent for tissue fixation and pathological diagnosis. However, it poorly preserves nucleic acids and this can impair molecular...
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Stress and breast cancer: from epidemiology to molecular biology
Stress exposure has been proposed to contribute to the etiology of breast cancer. However, the validity of this assertion and the possible mechanisms...
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The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma
BackgroundTo define a threshold value of apparent diffusion coefficient (ADC) with which malignant breast lesions can be distinguished from benign...
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Host Plant Responses to Virus Infection
The study of host responses to infection was of central importance in the development of plant virology up until the mid 1930s when the first viruses...