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Pathological phenotypes of astrocytes in Alzheimer’s disease
Astrocytes are involved in various processes in the central nervous system (CNS). As the most abundant cell type in the CNS, astrocytes play an...
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Immune cell phenotypes and mortality in the Framingham Heart Study
BackgroundGlobal life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable...
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Cross-ancestry genome-wide association studies of brain imaging phenotypes
Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely...
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Visualizing Macrophage Phenotypes and Polarization in Diseases: From Biomarkers to Molecular Probes
Macrophage is a kind of immune cell and performs multiple functions including pathogen phagocytosis, antigen presentation and tissue remodeling. To...
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Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Our understanding of the genetics of the human cerebral cortex is limited both in terms of the diversity and the anatomical granularity of brain...
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Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells
BackgroundCirculating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However,...
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Gender disparities in Behçet’s syndrome: identifying distinct phenotypes through cluster analysis
Behçet’s syndrome (BS) is a complex, multi-systemic disorder with a global occurrence, notably concentrated along the Silk Road. This study aimed to...
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Wisconsin diversity panel phenotypes: spoken descriptions of plants and supporting data
ObjectivesPhenoty** plants in a field environment can involve a variety of methods including the use of automated instruments and labor-intensive...
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Single cell atlas of kidney cancer endothelial cells reveals distinct expression profiles and phenotypes
BackgroundTumor endothelial cells (TECs) represent the primary interface between the tumor microenvironment and circulating immune cells, however...
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Pharmacogenomic study—A pilot study of the effect of pharmacogenomic phenotypes on the adequate dosing of verapamil for migraine prevention
ObjectiveTo investigate factors affecting the efficacy and tolerability of verapamil for migraine prevention using individual pharmacogenomic...
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Modelling ADHD-Like Phenotypes in Zebrafish
The use of multiple species to model complex human psychiatric disorders, such as ADHD, can give important insights into conserved evolutionary...
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Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly...
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Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Chronic arsenic exposure is considered to increase the risk of breast cancer. p62 is a multifunctional adaptor protein that controls myriad cellular...
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Could senescence phenotypes strike the balance to promote tumor dormancy?
After treatment and surgery, patient tumors can initially respond followed by a rapid relapse, or respond well and seemingly be cured, but then recur...
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Different phenotypes of microglia in animal models of Alzheimer disease
Microglia are immune-competent cells that are critically involved in maintaining normal brain function. A prominent characteristic of Alzheimer...
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Genetic and environmental effects on morphological traits of social phenotypes in wasps
Many species exhibit distinct phenotypic classes, such as sexes in dioecious species or castes in social species. The evolution of these classes is...
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Detection of disease-associated microglia among various microglia phenotypes induced by West Nile virus infection in mice
West Nile virus (WNV) has emerged as a significant cause of viral encephalitis in humans and horses. However, the pathogenesis of the West Nile...
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Genetic Phenotypes of Alzheimer’s Disease: Mechanisms and Potential Therapy
Years of intensive research has brought us extensive knowledge on the genetic and molecular factors involved in Alzheimer's disease (AD). In addition...
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CTNNA1, a New HDGC Gene: Inactivating Mechanisms and Driven Phenotypes
This chapter focuses on CTNNA1, the second gene to be acknowledged as a hereditary diffuse gastric cancer (HDGC) predisposing gene. CTNNA1 loss of...
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Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks
Within population biobanks, incomplete measurement of certain traits limits the power for genetic discovery. Machine learning is increasingly used to...
