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Mechanisms underlying spontaneous phasic contractions and sympathetic control of smooth muscle in the rat caudal epididymis
Here we investigate mechanisms underlying spontaneous phasic contractions (SPCs) and sympathetic control of contractility in the rat epididymis, a...
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β-Amyloid and Lithium Affect the Magnitude of Phasic Dopamine Release in the Shell of the Nucleus Accumbens
Published data indicate that impairments to dopaminergic secretion in the shell of the nucleus accumbens play a role in the pathogenesis of...
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Imaging Neuropeptide Release at Drosophila Neuromuscular Junction with a Genetically Engineered Neuropeptide Release Reporter
Despite the important roles of neuropeptides in a variety of physiological processes, there still lacks a method to probe neuropeptide release events...
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Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia
Gabapentinoids are effective drugs in most animal models of pain and inflammation with variable effects in humans. The current study evaluated the...
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Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review
This review is on how current knowledge of brainstem control of gastric mechanical function unfolded over nearly four decades from the perspective of...
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Development of an Accelerated Rotator-based Drug Release Method for the Evaluation of Bupivacaine Multivesicular Liposomes
PurposeA multivesicular liposome (MVL) is a liposomal vehicle designed to achieve sustained release characteristics for drugs with short half-lives....
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Age-dependent effects of social isolation on mesolimbic dopamine release
In humans, social isolation is a known risk factor for disorders such as substance use disorder and depression. In rodents, social isolation is a...
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QBD Approach for Design and Characterization of Pramlintide Microspheres for Controlled Drug Release
PurposeThe research was centered on the optimization of the microsphere formulation through a systematic quality-by-design (QBD) methodology, as well...
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Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Remote loading microencapsulation of peptides into polymer microspheres without organic solvent represents a promising alternative to develop...
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Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1
Neural systems encode information in the frequency of action potentials, which is then decoded by synaptic transmission. However, the rapid,...
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GABA tone regulation and its cognitive functions in the brain
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at GABAergic synapses, mediating fast-acting phasic inhibition. Emerging...
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Voltammetry in the spleen assesses real-time immunomodulatory norepinephrine release elicited by autonomic neurostimulation
BackgroundThe noradrenergic innervation of the spleen is implicated in the autonomic control of inflammation and has been the target of...
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Convolution- and Deconvolution-Based Approaches for Prediction of Pharmacokinetic Parameters of Diltiazem Extended-Release Products in Flow-Through Cell Dissolution Tester
The present study evaluated the effect of different configuration setups of the Flow-Through Cell (USP IV) dissolution tester in develo** in...
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The Role of Tomosyn in the Regulation of Neurotransmitter Release
Soluble NSF attachment protein receptor (SNARE) proteins play a central role in synaptic vesicle (SV) exocytosis. These proteins include the...
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Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human
This review is a revisit of various oral drug absorption models developed in the past decades, focusing on how to incorporate the physiological...
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A TAN-dopamine interaction mechanism based computational model of basal ganglia in action selection
The basal ganglia (BG) plays a key role in action selection. Physiological experiments have suggested that the reciprocal interaction between...
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Differential Influence of Amyloid-β on the Kinetics of Dopamine Release in the Dorsal and Ventral Striatum of Rats
Dopaminergic dysfunction is a part of Alzheimer’s disease pathology. The brain accumulation of amyloid-β of toxic form is a key link of the...
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Involvement of ANO1 currents in pacemaking of PDGFRα-positive specialised smooth muscle cells in rat caudal epididymis
The epididymal duct exhibits spontaneous phasic contractions (SPCs) to store and transport sperm. Here, we explored molecular identification of...
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Cannabidiol inhibits methamphetamine-induced dopamine release via modulation of the DRD1-MeCP2-BDNF-TrkB signaling pathway
RationaleAdaptive alteration of dopamine (DA) system in mesocorticolimbic circuits is an extremely intricate and dynamic process, which contributes...
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GABAB receptors constrain glutamate presynaptic release and postsynaptic actions in substantia gelatinosa of rat spinal cord
The substantia gelatinosa (SG, lamina II of spinal cord gray matter) is pivotal for modulating nociceptive information from the peripheral to the...
