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On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy
Epilepsy is a complex disease mainly defined by the susceptibility to spontaneous recurrent seizures but is also often associated with complex...
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Pharmacoresistance in Epilepsy From Genes and Molecules to Promising Therapies
This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as...
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Pharmacoresistance in Epilepsy
Although more than 30 anti-seizure medications are available on the market, epilepsy remains pharmaco-resistant in 30% of patients with focal...
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Neonatal Excitotoxicity Triggers Degenerative Processes Related to Seizure Susceptibility and Pharmacoresistance
Neuronal damage and seizures are two closely related events, not only reciprocally as cause and effect but also through the cellular mechanisms and...
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Cerebrovascular Remodeling and the Role of Vascular Endothelial Growth Factor in the Epileptic Brain and Pharmacoresistance
The neurovascular unit plays a relevant role in normal situations and pathological conditions involving the nervous system. In epileptic conditions,...
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GABAergic Neurotransmission Abnormalities in Pharmacoresistant Epilepsy: Experimental and Human Studies
Despite the fact that there are several drugs available for the treatment of epilepsy, pharmacoresistance remains a major challenge in seizure...
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The Role of JNK3 in Epilepsy and Neurodegeneration
N-terminal kinases (JNKs) belong to the subfamily of mitogen-activated protein kinases (MAPKs). JNKs are considered central signal transducers in the...
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Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the...
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Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2
Epilepsy is a neurological disease characterized by abnormal or synchronous brain activity causing seizures, which may produce convulsions, minor...
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Age-Dependent Phenomena of 6-Hz Corneal Kindling Model in Mice
Although numerous studies have acknowledged disparities in epilepsy-related disease processes between young and aged animals, little is known about...
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Role of MicroRNAs in Cell Growth Proliferation and Tumorigenesis
MicroRNAs (miRNAs) are a type of short noncoding RNA that regulates a broad range of biological processes, including cancer development. MiRNAs have...
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Drug-Resistant Epilepsy and the Influence of Age, Gender, and Comorbid Disorders
In the study of drug-resistant epilepsy (DRE), certain important characteristics remain poorly understood such as the age and gender of patients and...
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Neurobehavioral protective effects of Japanese sake yeast supplement against chronic stress-induced anxiety and depression-like symptoms in mice: Possible role of central adenosine receptors
RationaleUsing routine synthetic drugs in the treatment of psychiatric disorders may have some restrictions due to serious side effects and...
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Contribution of the Antiepileptic Drug Administration Regime to Avoid the Development and/or Establishment of Pharmacoresistant Epilepsy
Although drug-resistant epilepsy has been explained by different mechanisms, the most accepted one involves overexpression of efflux transporters at...
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Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy
Pharmacoresistance in epilepsy is a major challenge to successful clinical therapy. Glucocorticoid receptor (GR) dysregulation can affect the...
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GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome
BackgroundThe complex pathophysiology of epilepsy hampers the development of effective treatments. Although more than ten kinds of anti-seizures...
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Cortical stimulation in pharmacoresistant focal epilepsies
Pharmacoresistance and adverse drug events designate a considerable group of patients with focal epilepsies that require alternative treatments such...
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On the Development of New Drugs for the Treatment of Drug-Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses
Despite the continuous expansion of the available pharmacological options for the treatment of epilepsies and remarkable advances in understanding...