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Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display
BackgroundMonoclonal antibody (mAb)-based immunotherapies have achieved promising outcomes in the treatment of immunological and oncological...
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Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques
Schistosomiasis, a challenging neglected tropical disease, affects millions of people worldwide. Develo** a prophylactic vaccine against Schistosoma...
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Screening and identification of cyprinid herpesvirus 2 (CyHV-2) ORF55-interacting proteins by phage display
BackgroundCyprinid herpesvirus 2 (CyHV-2) is a pathogenic fish virus belonging to family Alloherpesviridae. The CyHV-2 gene encoding thymidine kinase...
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Structure-based design and construction of a synthetic phage display nanobody library
ObjectiveTo design and construct a new synthetic nanobody library using a structure-based approach that seeks to maintain high protein stability and...
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Protocol for Differential Biopanning of P. falciparum Phage Display cDNA Library to Identify Parasite Targets of Protective Antibodies
Malaria remains a significant global health burden, killing hundreds of thousands of children annually (WHO, The world malaria report. WHO, Geneva,...
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A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms
Phage display technology allows for rapid selection of antibodies from the large repertoire of human antibody fragments displayed on phages. However,...
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Phage Display Technology and the Development of Phage-Based Vaccines
A great many phages are amenable to a range of common genetic manipulations. They are also easy to propagate to high numbers and simple to handle....
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Phage Immunoprecipitation Sequencing (PhIP-Seq) for Analyzing Antibody Epitope Repertoires Against Food Antigens
While thousands of food and environmental allergens have been reported, conventional methods for allergy testing typically rely on measuring...
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Identification of COVID-19 B-cell epitopes with phage-displayed peptide library
BackgroundCoronavirus disease 19 (COVID-19) first appeared in the city of Wuhan, in the Hubei province of China. Since its emergence, the...
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Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
Develo** therapeutic antibodies is laborious and costly. Here we report a method for antibody discovery that leverages the Illumina HiSeq platform...
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Morphological, biological, and genomic characterization of Klebsiella pneumoniae phage vB_Kpn_ZC2
BackgroundBacteriophages (phages) are one of the most promising alternatives to traditional antibiotic therapies, especially against...
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Map** human norovirus antigens during infection reveals the breadth of the humoral immune response
Human noroviruses (HuNoV) are the leading cause of acute gastroenteritis worldwide. The humoral immune response plays an important role in clearing...
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Isolation of Antibody Binders to MISIIR from a Phage Display Library by Sorting
Cell surface antigens represent the most common targets for antibody-based cancer therapy. Isolation of lead antibodies to these membrane targets...
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Isolation of single-chain variable fragment (scFv) antibodies for detection of Chickpea chlorotic dwarf virus (CpCDV) by phage display
Chickpea chlorotic dwarf virus (CpCDV, genus Mastrevirus ), has a wide host range and geographic distribution in many parts of the world, and it is...
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Phage Display Technology and the Development of Phage-Based Vaccines
A great many phages are amenable to a range of common genetic manipulations. They are also easy to propagate to high numbers and simple to handle....
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PLA-PEG nanospheres decorated with phage display selected peptides as biomarkers for detection of human colorectal adenocarcinoma
Peptide-mediated targeting to colorectal cancer can increase selectivity and specificity of this cancer diagnosis acting as biomarkers. The present...
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Phage Display Screening for Alba Superfamily Proteins from the Human Malaria Parasite, Plasmodium falciparum Reveals a High Level of Association with Protein Modification Pathways and Hints at New Drug Targets
PurposeA 2016 study estimated that over 3 billion people are currently at risk of contracting malaria. Although a wide variety of medications are...
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Screening of Peptides that Specifically Binds to M3-M4 Extracellular Domain of Sodium Pump α1 Subunit and Analysis of Their Bioactivity In Vitro and In Vivo
Interaction between ouabain (OUA) and Na + /K + -pump remains in the current focus of hypertension research. This study aimed to find an oligopeptide...
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Targeting c-Met on gastric cancer cells through a fully human fab antibody isolated from a large naive phage antibody library
PurposeThe aberrant Hepatocyte growth factor (HGF)/ mesenchymal-epithelial transition factor (c-Met) signaling pathway in various malignancies and...
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Antibody Phage Display: Antibody Selection in Solution Using Biotinylated Antigens
Antibody phage display is the most used in vitro technology to generate recombinant, mainly human, antibodies as tools for research, for diagnostic...