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Antimicrobial Peptides
Purpose of ReviewThe review provides deep understanding on antimicrobial peptides, properties, mechanisms, role in treating diseases, computational...
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Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria
Multidrug-resistant (MDR) bacteria are considered a health threat worldwide, and this problem is set to increase over the decades. The ESKAPE, a...
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Peptides as multifunctional players in cancer therapy
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely, peptides demonstrate higher efficiency in tissue...
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Hemorphins—a Family of Atypical Opioid Peptides
AbstractHemorphins are a family of endogenous atypical opioid peptides released during the sequential cleavage of hemoglobin β-chain. Hemorphins are...
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Applications of peptides in nanosystems for diagnosing and managing bacterial sepsis
Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked to a significant...
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Beyond traditional translation: ncRNA derived peptides as modulators of tumor behaviors
Within the intricate tapestry of molecular research, noncoding RNAs (ncRNAs) were historically overshadowed by a pervasive presumption of their...
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How to Design Peptides
Novel design of proteins to target receptors for treatment or tissue augmentation has come to the fore owing to advancements in computing power,...
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Marine Peptides and Their Bioactive Potentials: New Horizon for Biotherapeutics
Marine ecosystems act as a reservoir of innumerable novel bioactive compounds by instigating stressful environments. Thus, marine bio-resources have...
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HDL Mimetic Peptides
Since therapeutic strategies designed to raise HDL failed to exert the expected effective cardiovascular disease (CVD) outcomes in clinical trials,...
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Antimicrobial peptides as potential therapy for gastrointestinal cancers
Since conventional therapy faces limitations in the field of different cancers as well as gastrointestinal cancers, that decrease the survival rate...
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Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines
AbstractThe extracellular matrix (ECM) is currently considered to be an important factor influencing the migration and progression of cancer cells....
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The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related...
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Impact of Organ Impairment on the Pharmacokinetics of Therapeutic Peptides and Proteins
The kidneys and liver are major organs involved in eliminating small-molecule drugs from the body. Characterization of the effects of renal...
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gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity
Apart from mediating viral entry, the function of the free HIV-1 envelope protein (gp120) has yet to be elucidated. Our group previously showed that...
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Naturally occurring and artificially designed antimicrobial peptides: a comparative study of Mastoparan C and BP52
Antimicrobial peptides (AMPs) are naturally occurring molecules that play a vital role in the innate immune responses of various organisms....
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Immobilised antimicrobial peptides in downregulation of biofilm
Colonisation of sessile bacterial species on biotic and abiotic surfaces is responsible for the development of various infections in humans. At...
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Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation
Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and reach the brain. Despite the importance of brain targeting in...
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Fluorescence Detection of Peptides, Proteins, Glycans
Peptides, proteins and glycansGlycans are major constituents of the living cells and their detection is very important for basic research and...
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Therapeutic potential of antimicrobial peptides against pathogenic protozoa
Protozoal infections cause significant morbidity and mortality in humans and animals. The use of several antiprotozoal drugs is associated with...
