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The role of rapid syndromic diagnostic testing of gastrointestinal pathogens as a clinical decision support tool in a pediatric emergency department
PurposeThis study aimed to investigate the role of rapid syndromic diagnostic testing of gastrointestinal pathogens as a clinical decision support...
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Factors associated with a basic common drug-drug interaction knowledge among emergency department medical personnel
BackgroundDrug-drug interactions (DDIs) are common but less concerning in clinical practice of time-sensitive situations. We aimed to identify...
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Clinical characterization of pediatric acute confusional migraine: a single-center case series
IntroductionAcute confusional migraine (ACM) is a rare disorder characteristic of pediatric patients. Our objective was to describe the clinical...
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Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers
Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold standard for evidence-based preclinical research in pediatric...
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Clozapine Toxicity in Two Young Siblings Due to a Pharmacy Dispensing Error: a Pediatric Case Report
IntroductionClozapine is an atypical antipsychotic used to treat refractory schizophrenia; in both therapeutic use and overdose, it can cause...
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Feasibility of three times weekly symptom screening in pediatric cancer patients
ObjectivePrimary objective was to determine the feasibility of three times weekly symptom reporting by pediatric cancer patients for eight weeks.
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Advances in the Diagnosis and Treatment of Pediatric Arterial Ischemic Stroke
Though rare, stroke in infants and children is an important cause of mortality and chronic morbidity in the pediatric population. Neuroimaging...
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Delta-8-Tetrahydrocannabinol Exposure and Confirmation in Four Pediatric Patients
IntroductionDelta-8-tetrahydrocannabinol (THC) is a known isomer of delta-9-THC, both found naturally in the Cannabis sativa plant and thought to...
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Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion
Integration of molecular data with histologic, radiologic, and clinical features is imperative for accurate diagnosis of pediatric central nervous...
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Exploring the molecular and clinical spectrum of COVID-19-related acute necrotizing encephalopathy in three pediatric cases
Acute necrotizing encephalopathy (ANE) is a rare disease that predominantly affects children and is associated with a high mortality rate. Here we...
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Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis
Sepsis arises from diverse and incompletely understood dysregulated host response processes following infection that leads to life-threatening organ...
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Curbside Consultations in Pediatric Dermatology: Risks and Benefits
Curbside consultations have always been a part of modern medical practice. Dermatology is given to this type of informal interaction in part due to...
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Truncal Ataxia and Prolonged Coma in an Exploratory Pediatric Perampanel Ingestion
IntroductionSeveral overdoses of the antiepileptic drug perampanel have been reported in adults, but very few have been reported in children. We...
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Deciphering the TLR transcriptome and downstream signaling pathway in cerebrospinal fluid in pediatric meningitis
Objective/designPediatric meningitis is characterized by a colossal inflammatory response to the pathogen in the central nervous system (CNS). This...
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Resurgence of SARS-CoV-2 Delta after Omicron variant superinfection in an immunocompromised pediatric patient
BackgroundPersistent SARS-CoV-2 infection in immunocompromised hosts is thought to contribute to viral evolution by facilitating long-term natural...
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SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants era
BackgroundCOVID-19, the coronavirus disease that emerged in December 2019, caused drastic damage worldwide. At the beginning of the pandemic,...
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Pediatric Suspected Suicides and Nonfatal Suicide Attempts Reported to United States Poison Control Centers Before and During the COVID-19 Pandemic
IntroductionThis study investigated the characteristics and compared the trends of pediatric suspected suicide and nonfatal suicide attempts reported...
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Pediatric spinal cord infarction following a minor trauma: a case report
IntroductionPediatric spinal cord infarction is a rare entity that presents a diagnostic challenge at the emergency department. Ischemic spinal cord...
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Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department
BackgroundAppropriate antibiotic prescribing is key to combating antimicrobial resistance. Upper respiratory tract infections (URTIs) are common...
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The Emergency Use Authorization of Pharmaceuticals: History and Utility During the COVID-19 Pandemic
The Emergency Use Authorization (EUA) originated in 2004 because of the need for emergency medical countermeasures (MCMs) against potential...