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Serum Interleukin-6 Levels as a Biomarker in Trauma
The degree of injury that occurs after trauma is proportional to the exposure of trauma energy exceeding the threshold of physiological tolerance of...
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Serum Angiotensin II as a Biomarker in COVID-19
Angiotensin II, synthesized by the cleavage of angiotensinogen to angiotensin I by renin and then conversion to angiotensin II by the...
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LC–MS Approach to Decipher a Light Chain Chromatographic Peak Splitting of a Monoclonal Antibody
PurposeMonoclonal antibodies (mAbs), like other protein therapeutics, are prone to various forms of degradation, some of which are difficult to...
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Serum and Plasma Proteomics for High Altitude Related Biomarker Discovery
Serum and plasma are widely used biological fluids for a large variety of biochemical and pathological tests which have been used since historical...
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Serum Interleukin-6 Levels as a Biomarker in Trauma
The degree of injury that occurs after trauma is proportional to the exposure of trauma energy exceeding the threshold of physiological tolerance of...
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Extended interval BNT162b2 vaccination enhances peak antibody generation
The BNT162b2 vaccine is highly effective against COVID-19 infection and was delivered with a 3-week time interval in registration studies
1 . However,...
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Ustekinumab during pregnancy and lactation: drug levels in maternal serum, cord blood, breast milk, and infant serum
BackgroundPatients with ulcerative colitis (UC) may be concerned about medication safety during preconception, pregnancy, and lactation, and they...
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Gentamicin Dosing in Neonates with Normal Renal Function: Trough and Peak Levels
Background and ObjectiveGentamicin is commonly used in neonates, and it requires drug concentration monitoring. The objective of this study was to...
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Establishment and Clinical Application in Stroke of a Serum Copeptin Time-Resolved Fluorescence Immunoassay
The serum biomarker copeptin, an innovative and stable substitute biomarker of vasopressin, is associated with stroke. Therefore, establishing a...
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Serum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort
BackgroundChanges in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular...
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Utilizing serum metabolomics for assessing postoperative efficacy and monitoring recurrence in gastric cancer patients
Objective(1) This study aims to identify distinct serum metabolites in gastric cancer patients compared to healthy individuals, providing valuable...
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Non-enzymatic Detection of Uric Acid in Serum and Urine by Fluorescent and Visual Dual-Mode Sensor Based on 3-aminophenylboric Acid Functionalized Carbon Dots
Herein, we developed a sophisticated dual-mode sensor that utilized 3-aminophenylboric acid functionalized carbon dots (APBA-CDs) to accurately...
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Generation of porcine circovirus type 4 virus-like particles and their use to detect serum antibodies
Porcine circovirus type 4 (PCV4), first identified in 2019 as a newly emerging pathogen, has been found in several provinces of China, as well as in...
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Serum Angiotensin II as a Biomarker in COVID-19
Angiotensin II, synthesized by the cleavage of angiotensinogen to angiotensin I by renin and then conversion to angiotensin II by the...
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An equation to predict peak heart rate for prescribing exercise intensity in middle-aged to older patients requiring hemodialysis
PurposeExercise prescription based on a population-specific physiological response can help ensure safe and effective physical interventions....
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The Role of Serum Matrix Metalloproteinase-9 as a Predictor of Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage
Delayed cerebral ischemia (DCI) is one of the major causes of a poor neurological outcome following aneurysmal subarachnoid hemorrhage (aSAH)....
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Serum small RNAs in metastatic colorectal cancer predict response to chemotherapy and characterize high-risk patients
Metastatic colorectal cancer (mCRC) presents significant challenges in clinical management due to its heterogeneity and variable response to...
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Thyroid Cancer: Quantum MicroRNA Language/Artificial Intelligence (MIRAI)-Based Etiologic Analysis of Thyroid Cancer by Serum/Plasma miRNA Panel Data
We have previously demonstrated that cancer pathogenesis can be simulated in silico by using a panel of circulating microRNAs (miRNAs) as biomarkers....
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Identification of common and distinct origins of human serum and breastmilk IgA1 by mass spectrometry-based clonal profiling
The most abundant immunoglobulin present in the human body is IgA. It has the highest concentrations at the mucosal lining and in biofluids such as...
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Smartphone Enabled Point-of-Care Detection of Serum Biomarkers
Sandwich immunoassays are the gold standard for detection of protein analytes. Here, we describe an ultrasensitive point-of-care sandwich immunoassay...