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Thymidine nucleotide metabolism controls human telomere length
Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely...
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AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice
There is growing evidence showing that adiponectin (APN) can improve Alzheimer’s disease(AD)-like pathological changes by improving insulin...
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Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice
The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 ...
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Exploring gene network and protein interaction analysis of neurotrophin signaling pathway in ameloblastoma
Ameloblastoma is a non-cancerous but aggressive oral tumor emerging from odontogenic epithelial tissue involved during odontogenesis. Since there is...
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Paternal lipopolysaccharide exposure induced intrauterine growth restriction via the inactivation of placental MEST/PI3K/AKT pathway in mice
Maternal lipopolysaccharide (LPS) exposure during pregnancy has been related to IUGR. Here, we explored whether paternal LPS exposure before mating...
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Transactivator of Transcription (Tat)-Induced Neuroinflammation as a Key Pathway in Neuronal Dysfunction: A Sco** Review
The activity of HIV-1 and its viral proteins within the central nervous system (CNS) is responsible for a wide array of neuropathological effects,...
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Aegeline attenuates TNBS-induced colitis by suppressing the NFƙB-mediated NLRP3 inflammasome pathway in mice
A chronic inflammatory condition of the intestine, ulcerative colitis (UC), is challenging to successfully manage once diagnosed. Currently,...
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Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway
Unlike megabats, which rely on well-developed vision, microbats use ultrasonic echolocation to navigate and locate prey. To study ultrasound...
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Pathway-Specific Chemogenetic Manipulation by Applying Ligand to Axonally Expressed DREADDs
New tools for controlling neural populations such as opto- and chemogeneticsChemogenetics afford unprecedented precision in pinpointing the neural...
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CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway
Contactin-associated protein-like 2 ( CNTNAP2 ) gene, located on chromosome 7q35, is one of the largest genes in the human genome. CNTNAP2 protein is a...
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Length Measurement of Cholinergic Innervation in the Tunica Albuginea of Rat Testis
The testicular albuginea is not a simple receptacle that contains the testis parenchyma. It is a biologically active structure involved, among other...
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The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases
Pattern recognition receptors are an essential part of the immune system, which detect pathogen-associated molecular patterns (PAMPs) and...
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Synergistic effect of YOD1 and USP21 on the Hippo signaling pathway
BackgroundDeubiquitinating enzymes (DUBs) comprise a family of proteases responsible for cleaving the peptide or isopeptide bond between ubiquitin...
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HIF-1α Pathway Orchestration by LCN2: A Key Player in Hypoxia-Mediated Colitis Exacerbation
In this study, we investigated the role of hypoxia in the development of chronic inflammatory bowel disease (IBD), focusing on its impact on the...
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SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation
Oncolytic viruses (OVs) are emerging as a potentially useful treatment for malignancies due to the capabilities of direct oncolysis and immune...
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Sonic Hedgehog Signaling Pathway: A Role in Pain Processing
Pain, as one of the most prevalent clinical symptoms, is a complex physiological and psychological activity. Long-term severe pain can become...
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Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors
BackgroundColon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt...
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Transcriptomic Analysis of Cyclamen persicum to Identify Invovled Genes in Triterpene Secondary Metabolites Pathway
Saponins are considered as a diverse group of natural active compounds, which are widely found in crops. Mevalonate pathway (MVA) is regarded as the...
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A hypothalamic pathway that suppresses aggression toward superior opponents
Aggression is costly and requires tight regulation. Here we identify the projection from estrogen receptor alpha-expressing cells in the caudal part...
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Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson’s Disease
Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons, with ferroptosis playing a significant role. Salidroside (SAL) has...
