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Sonic Hedgehog Cell Signaling Pathway and Medulloblastoma
The Sonic hedgehog cell signaling pathway is responsible for the cellular differentiation of embryonic cells. Interestingly, different parts of the...
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Notch Cell Signaling Pathway and Brain Tumors
The Notch signaling pathway is highly conserved in most organisms (Artavanis-Tsakonas et al. 1999). There are four different types of Notch receptors...
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Wnt Cell Signaling Pathway in Brain Tumor Development
The Wnt cell signaling pathway originated from wingless and the name Int-1 (Nusse et al. 1991) has both paracrine (nearby cell–cell communication)...
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Wnt/β-catenin pathway is a key signaling pathway to trastuzumab resistance in gastric cancer cells
BackgroundTrastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive...
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Interaction between Wnt/β-catenin signaling pathway and EMT pathway mediates the mechanism of sunitinib resistance in renal cell carcinoma
BackgroundTargeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the...
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Cholesterol biosynthetic pathway induces cellular senescence through ERRα
Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated...
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Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers
Lung cancer is the primary contributor to cancer-related deaths globally, and non-small cell lung cancer (NSCLC) constitutes around 85% of all lung...
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Biochemical Mechanistic Pathway of Cell Death Induced by Metal-Based Chemotherapeutic Agents
A large plethora of metal complexes that could act as potent anticancer chemotherapeutic agents have been designed and developed in the recent past...
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Sirt1 inhibits macrophage polarization and inflammation in gouty arthritis by inhibiting the MAPK/NF-κB/AP-1 pathway and activating the Nrf2/HO-1 pathway
Objective and designTo elucidate Sirt1’s role in gouty arthritis inflammation and its potential mechanisms.
MaterialConstructed murine models of...
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Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice
The basal ganglia are essential for executing motor actions. How the basal ganglia engage spinal motor networks has remained elusive. Medullary Chx10 ...
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Defense Against Oxidative Stress: Nrf2-ARE Pathway
Reactive chemical intermediates, including reactive oxygen and nitrogen species and free radicals, are formed during foreign compound metabolic...
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Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy
Protein arginine methyltransferases (PRMTs) modulate diverse cellular processes, including stress responses. The present study explored the role of...
