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Cancer vaccines from cryogenically silicified tumour cells functionalized with pathogen-associated molecular patterns
The production of personalized cancer vaccines made from autologous tumour cells could benefit from mechanisms that enhance immunogenicity. Here we...
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Pathogen–Host Interaction and Its Associated Molecular Mechanism in HFMD Pathology and Immunology
Hand, foot, and mouth disease (HFMD) is caused by the enterovirus family, which includes EV-A71 and more than 10 other members. The disease involves...
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Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock
Most bacterial vaccines work for a subset of bacterial strains or require the modification of the antigen or isolation of the pathogen before vaccine...
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Effects of bacterial and viral pathogen-associated molecular patterns (PAMPs) on multidrug resistance (MDR) transporters in brain endothelial cells of the develo** human blood–brain barrier
BackgroundThe multidrug resistance (MDR) transporters, P-glycoprotein (P-gp, encoded by ABCB1 ) and breast cancer resistance protein (BCRP/ ABCG2 )...
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Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases
Both mitochondrial dysfunction and neuroinflammation are implicated in neurodegeneration and neurodegenerative diseases. Accumulating evidence shows...
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Structuring Inflammasome-Epigenome: Phenotypic Axis in Gynecological Cancers
Inflammasomes are made up of sensor proteins, caspase domain having adaptor protein, and caspase-1 aka pro-inflammatory caspase present in the...
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Molecular Tools for Characterizing AMR Pathogens
Antimicrobial resistance in bacterial pathogens is growing at a rapid pace. The problem of AMR has percolated to different sectors. The first and...
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Molecular Tools for Characterizing AMR Pathogens
Antimicrobial resistance in bacterial pathogens is growing at a rapid pace. The problem of AMR has percolated to different sectors. The first and...
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Multifaceted Molecular Targets of Anti-Inflammatory Agents from Ayurvedic Plants
The relationship between prolonged inflammation and the occurrence of different fatal diseases like cancer was first identified in the nineteenth...
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Molecular biology of autoinflammatory diseases
The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage,...
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Genomic characterization and molecular evolution of human monkeypox viruses
Monkeypox virus is a member of the family Poxviridae , as are variola virus and vaccinia virus. It has a linear double-strand DNA genome approximately...
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Toll-like Receptors in Health and Disease
The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For...
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Structuring Inflammasome-Epigenome – Phenotypic Axis in Gynecological Cancers
Inflammasomes are made up of sensor proteins, caspase domain having adaptor protein, and caspase-1 aka pro-inflammatory caspase present in the...
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Tracking the molecular evolution and transmission patterns of SARS-CoV-2 lineage B.1.466.2 in Indonesia based on genomic surveillance data
BackgroundAs a new epi-center of COVID-19 in Asia and a densely populated develo** country, Indonesia is facing unprecedented challenges in public...
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Biochemical, Molecular, and Computational Techniques for the Determination of Virulence Factors of ESKAPE Pathogens
Emerging antibiotic resistance and its spreading dynamics have reached an alarming level, a global challenge. Overuse and Misuse of effective...
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Molecular epidemiology of the HIV-1 epidemic in Fiji
Very little is known about the HIV-1 epidemic in Fiji, nor the wider South Pacific region more generally, yet new reported HIV-1 infections are on...
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Cellular and Molecular Mechanisms of Neuroinflammation in Drug-Resistant Epilepsy
Drug-resistant epilepsy (DRE) is characterized by the persistence of epileptic seizures despite the administration of antiepileptic treatments. The...
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Use of Fluorescent Chemical Probes in the Study of Toll-like Receptors (TLRs) Trafficking
Fluorescent chemical probes are used nowadays as a chemical resource to study the physiology and pharmacology of several important endogenous...
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Molecular Evolution
Molecular evolution occurs in the genome in the form of substitutions, insertion/deletion, recombination and gene conversion. The principles of...
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Ecological patterns and processes of temporal turnover within lung infection microbiota
BackgroundChronic infection and consequent airway inflammation are the leading causes of morbidity and early mortality for people living with cystic...
