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Association of systemic inflammation with the obesity paradox in cancer: results from multi-cohort studies
AimsThis study aimed to explore whether the obesity paradox exists in overall and specific cancers and to investigate the role of systemic...
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Adiponectin, the adiponectin paradox, and Alzheimer’s Disease: Is this association biologically plausible?
Dementia, especially Alzheimer’s Disease (AD) and vascular dementia, is a major public health problem that continues to expand in both economically...
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Autonomic variability, depression and the disability paradox in spinal cord injury
Study designLongitudinal.
ObjectiveWith an increased risk of depression in spinal cord injury, the study longitudinally examines depression to...
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The vascularization paradox of non-union formation
Despite major research efforts to elucidate mechanisms of non-union formation, failed fracture healing remains a common complication in orthopedic...
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Exploring the levodopa-paradox of freezing of gait in dopaminergic medication-naïve Parkinson’s disease populations
The relationship between dopaminergic treatment and freezing of gait (FOG) in Parkinson’s disease (PD) is complex: levodopa is the most effective...
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A comparison of analytic approaches for investigating the obesity paradox in kidney cancer
PurposeBody mass index (BMI) and kidney cancer mortality are inconsistently associated in the scientific literature. To understand how study design...
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Addressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues
BackgroundSince fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September...
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Towards resolution of the intron retention paradox in breast cancer
BackgroundAfter many years of neglect in the field of alternative splicing, the importance of intron retention (IR) in cancer has come into focus...
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Unveiling the Biosimilar Paradox of Oncologists’ Perceptions and Hesitations in South Korea: A Web-Based Survey Study
IntroductionBiosimilars offer a cost-effective alternative to original biopharmaceuticals with comparable efficacy and safety. The perception and...
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The obesity paradox in metastatic castration-resistant prostate cancer
ObjectiveTo test whether body mass index (BMI) amongst patients with metastatic castration-resistant prostate cancer (mCRPC) is associated with...
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Why scientists, academic institutions, and investors fail in bringing more products to the bedside: the Active Compass model for overcoming the innovation paradox
The vast majority of good science and excellent ideas do not translate into products. Many good products that have the potential to assist in...
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Examining the paradox: increased malaria risk in children under 5 in female-headed households in Nigeria
BackgroundNigeria is facing a severe malaria crisis, accounting for a significant proportion of global cases and deaths of malaria. This study aimed...
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The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent...
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Heart Failure and the Obesity Paradox
Heart failure (HF) represents a complex cardiovascular disease with a wide range of risk factors, different pathophysiology, and various...
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A novel mechanism of ACE inhibition–associated enhanced platelet reactivity: disproof of the ARB-MI paradox?
PurposeACE inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are important drugs in cardiovascular disease. However, little is known about...
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Using oral tegafur/uracil (UFT) plus leucovorin as adjuvant chemotherapy in stage II colorectal cancer: a propensity score matching study from Taiwan
BackgroundEarly-stage colorectal cancer had excellent outcomes after curative resection, typically. However, a perplexing survival paradox between...
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The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy
Obesity is nowadays considered a pandemic which prevalence’s has been steadily increasingly in western countries. It is a dynamic, complex, and...
