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Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis
BackgroundCharacterizing immune cells and conditions that govern their recruitment and function in autoimmune diseases of the nervous system or in...
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Parabiosis: Assessing the Effects of Circulating Cells and Factors on the Skeleton
The circulatory system carries within it numerous types of cells, proteins, and other factors that are able to influence the local biology of...
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Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice
γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to...
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Blood-to-brain communication in aging and rejuvenation
Aging induces molecular, cellular and functional changes in the adult brain that drive cognitive decline and increase vulnerability to...
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Redefining the ontogeny of hyalocytes as yolk sac-derived tissue-resident macrophages of the vitreous body
BackgroundThe eye is a highly specialized sensory organ which encompasses the retina as a part of the central nervous system, but also non-neural...
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Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing
BackgroundThe gut microbiota is associated with diverse age-related disorders. Several rejuvenation methods, such as probiotic administration and...
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Role of circulating molecules in age-related cardiovascular and metabolic disorders
Studies analyzing heterochronic parabiosis mice models showed that molecules in the blood of young mice rejuvenate aged mice. Therefore, blood-based...
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The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease
More and more evidences are proving that microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD) and the plasma Aβ 1-42 levels...
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Interleukin-1β Protection Against Experimental Sepsis in Mice
The inflammatory response involving interleukin-1β (IL-1β) has been thought to play an important role in the development of late-phase sepsis....
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Blood-based therapies to combat neurodegenerative diseases
Neurodegeneration, known as the progressive loss of neurons in terms of their structure and function, is the principal pathophysiological change...
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Aging, Causes, and Rejuvenation of Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) undergo an age-related functional decline, which leads to a disruption of the blood system and contributes to the...
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Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors
BackgroundRegulation of cerebral blood flow (CBF) directly influence brain functions and dysfunctions and involves complex mechanisms, including...
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The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model
Mucosal healing occurs through migration and proliferation of cells within injured epithelium, yet these processes may be inadequate for mucosal...
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Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasma
Aging is accompanied by alterations in the body with time-related to decline of physiological integrity and functionality process, responsible for...
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Skull bone marrow channels as immune gateways to the central nervous system
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull...
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Long-term maintenance of lung resident memory T cells is mediated by persistent antigen
Tissue-resident memory T cells (T RM ) in the lungs are pivotal for protection against repeated infection with respiratory viruses. However, the...
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Toward a Dimension-Free, Pre-Emptive, Integrated Health Risk Assessment of Chemicals
Recent studies show the peripheral origin of the disease in the central nervous system such as Parkinson’s disease, Alzheimer’s disease, ADHD, and...
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