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Neurodegeneration and Neuroinflammation: The Role of Pannexin 1
Abstract—Pannexins are capable of forming in the cell membrane anion channels with relatively low conductivity, as well as channels with high...
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Mechanisms of ATP release in pain: role of pannexin and connexin channels
Pain is a physiological response to bodily damage and serves as a warning of potential threat. Pain can also transform from an acute response to...
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Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses
BackgroundNeuropathic pain is still a challenge for clinical treatment as a result of the comprehensive pathogenesis. Although emerging evidence...
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Pannexin 3 channels in health and disease
Pannexin 3 (PANX3) is a member of the pannexin family of single membrane channel-forming glycoproteins. Originally thought to have a limited...
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Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury
Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance channels that are central to many distinct inflammation and injury...
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Pannexin 1 channels and ATP release in epilepsy: two sides of the same coin
Purinergic signaling mediated by ATP and its metabolites contributes to various brain physiological processes as well as to several pathological...
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The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus
Only recently, the role of large ionic channels such as Pannexin-1 channels and Connexin hemichannels has been implicated in several physiological...
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Involvement of Pannexin-1 in the Mechanism of Deprivation Potentiation of Population Spikes of Neurons in Rat Hippocampal Field CA1
Testing of the connections of Schaffer collaterals with field CA1 neurons in living slices of rat hippocampus was used to study the mechanism of...
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Pannexin-1 channel “fuels” by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells
An efficient harvest of hematopoietic stem/progenitor cells (HSPCs) after pharmacological mobilization from the bone marrow (BM) into peripheral...
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Pannexin-1 Channel Regulates ATP Release in Epilepsy
With the deepening of research on epilepsy in recent decades, great progress has been made in the diagnosis and treatment of the disease. However,...
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Oxidative stress and inflammation cause auditory system damage via glial cell activation and dysregulated expression of gap junction proteins in an experimental model of styrene-induced oto/neurotoxicity
BackgroundRedox imbalance and inflammation have been proposed as the principal mechanisms of damage in the auditory system, resulting in functional...
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Myeloid Pannexin-1 mediates acute leukocyte infiltration and leads to worse outcomes after brain trauma
BackgroundNeuroinflammation is a major component of secondary damage after traumatic brain injury (TBI). We recently reported that pharmacological...
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PUFAs supplementation affects the renal expression of pannexin 1 and connexins in diabetic kidney of rats
In diabetic nephropathy (DN), intercellular communication is disrupted. Connexins (Cx) have a crucial role in that process. Dietary ratios and...
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P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission
Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence has been reported about the role of this nucleotide and...
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An Overview of Chemistry, Kinetics, Toxicity and Therapeutic Potential of Boldine in Neurological Disorders
Boldine is an alkaloid obtained from the medicinal herb Peumus boldus (Mol.) (Chilean boldo tree; boldo) and belongs to the family Monimiaceae. It...
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Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes
Paracrine ATP release by erythrocytes has been shown to regulate endothelial cell function via purinergic signaling, and this erythoid-endothelial...
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Probenecid Relieves Cerebral Dysfunction of Sepsis by Inhibiting Pannexin 1-Dependent ATP Release
Acute brain dysfunction and the following neurological manifestation are common complications in septic patients, which are associated with increased...
