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Increased levels of the synaptic proteins PSD-95, SNAP-25, and neurogranin in the cerebrospinal fluid of patients with Alzheimer’s disease
BackgroundThere is currently a lack of reliable and easily accessible biomarkers predicting cognitive decline in Alzheimer’s disease (AD). Synaptic...
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Neuroprotection of sevoflurane against ischemia/reperfusion-induced brain injury through inhibiting GluN2A/GluN2B-PSD-95-MLK3 module
To investigate the role of GluN2A and GluN2B in neuroprotective effect of sevoflurane preconditioning against cerebral ischemia–reperfusion injury...
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Neuroprotective Effects Against Cerebral Ischemic Injury Exerted by Dexmedetomidine via the HDAC5/NPAS4/MDM2/PSD-95 Axis
Numerous evidences have highlighted the efficient role of dexmedetomidine (DEX) in multi-organ protection. In the present study, the neuroprotective...
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A Compound Mitigates Cancer Pain and Chemotherapy-Induced Neuropathic Pain by Dually Targeting nNOS-PSD-95 Interaction and GABAA Receptor
Metastatic bone pain and chemotherapy-induced peripheral neuropathic pain are the most common clinical symptoms in cancer patients. The current...
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Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions
Postsynaptic density protein 95 (PSD-95) is a pivotal postsynaptic scaffolding protein in excitatory neurons. Although the transport and regulation...
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Interaction Between CRIPT and PSD-95 Is Required for Proper Dendritic Arborization in Hippocampal Neurons
CRIPT, the cysteine-rich PDZ-binding protein, binds to the third PDZ domain of PSD-95 (postsynaptic density protein 95) family proteins and directly...
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Factors correlating the expression of PD-L1
ObjectivePD-L1 was an important biomarker in lung adenocarcinoma. The study was to confirm the most important factor affecting the expression of...
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The Postsynaptic Density
The postsynaptic density is a dense, submembranous filamentous structure beneath the postsynaptic membrane. It is a disklike structure that may or...
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Induction of Phosphorylated Tau Accumulation and Memory Impairment by Bisphenol A and the Protective Effects of Carnosic Acid in In Vitro and In Vivo
Bisphenol A (BPA) is a component of polycarbonate plastics that has been implicated in memory impairment. The present study investigated the effect...
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Neonatal phencyclidine as a model of sex-biased schizophrenia symptomatology in adolescent mice
Sex-biased differences in schizophrenia are evident in several features of the disease, including symptomatology and response to pharmacological...
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Ferulic Acid Improves Synaptic Plasticity and Cognitive Impairments by Alleviating the PP2B/DARPP-32/PP1 Axis-Mediated STEP Increase and Aβ Burden in Alzheimer’s Disease
The burden of Alzheimer’s disease, the most prevalent neurodegenerative disease, is increasing exponentially due to the increase in the elderly...
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Inhibition of CSPG-PTPσ Activates Autophagy Flux and Lysosome Fusion, Aids Axon and Synaptic Reorganization in Spinal Cord Injury
Chondroitin sulfate proteoglycans (CSPGs) and proteoglycan receptor protein tyrosine phosphatase σ (PTPσ) play a critical role in the pathology of...
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Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats
It remains unclear whether exposure to sevoflurane produces different effects on long-term cognitive function in develo** and mature brains. In the...
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Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology
Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal...
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Hippocampal synaptic dysfunction and spatial memory impairment in omeprazole-treated rats
Although the association of prolonged use of proton pump inhibitors, such as omeprazole, with memory impairment has been reported more than two...
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Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation
In the nervous system, only one type of neuron–glial synapse is known to exist: that between neurons and oligodendrocyte precursor cells (OPCs), yet...
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Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway
Depression is a common psychological disease with high morbidity and mortality. Recently, the involvement of synaptic plasticity in the pathogenesis...
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Dorsal hippocampal astrocytes mediate the development of heroin withdrawal-enhanced fear learning
There is a significant co-occurrence of opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) in clinical populations. However, the...
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Effects of different exercise modes and intensities on cognitive performance, adult hippocampal neurogenesis, and synaptic plasticity in mice
Exercise can induce beneficial improvements in cognition. However, the effects of different modes and intensities of exercise have yet to be explored...
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Noninvasive Deep Brain Stimulation via Temporal Interference Electric Fields Enhanced Motor Performance of Mice and Its Neuroplasticity Mechanisms
A noninvasive deep brain stimulation via temporal interference (TI) electric fields is a novel neuromodulation technology, but few advances about TI...
