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The Peptide ACTH4–7-PGP Corrects Behavior and Corticosterone Levels in Rats in Chronic Stress
The peptide ACTH 4–7 -PGP has a wide spectrum of neuroprotective actions, including antioxidant and antidepressant effects in stress conditions. One...
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Effects of Peptides ACTH6–9 PGP and ACTH4–7-PGP on Anxiety Levels in Rats in Punished and Unpunished Behavior
Melanocortins form a class of regulatory peptide currently under active study; these include such biologically active substances as...
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Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax)
We studied the effect of intraperitoneal administration ACTH (4-7) -PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before...
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Peptide ACTH4-7-PGP: Effects on Various Types of Pain and Pain-Induced Behavior in Rats after Systemic and Central Administration
The effects of peptide ACTH4-7-PGP (Semax) were studied in 12 min after its intraperitoneal (in doses of 5, 15, 50, 150, and 450 μg/kg) or...
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Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System
PurposeSerotonin (5-HT 3 ) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the...
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Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein
The ATP-binding cassette subfamily B member 1 (ABCB1), encoding a multidrug transporter referred to as P-glycoprotein (Pgp), plays a critical role in...
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Functioning of P-Glycoprotein during Pregnancy in Rabbits
The level P-glycoprotein (Pgp) in organs of pregnant rabbits and its content and activity in the placental barrier at different stages of pregnancy...
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Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin
Compared to rifampicin (600 mg/day), standard doses of rifabutin (300 mg/day) have a lower risk of drug–drug interactions due to induction of...
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Synergistic effect of Punica granatum derived antifungals on strains with clinical failure to terbinafine and azoles drugs
Dermatomycosis is a commonly occurring widespread superficial fungal infection. The infection is mostly caused by the dermatophytes (e.g., Trichophyton ...
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Effects of ACTH6-9-Pro-Gly-Pro Peptide on the Levels of Pro- and Anti-Inflammatory Cytokines in Wistar Rats under Conditions of Chronic Restraint Stress
We evaluated the effect of ACTH 6-9 -Pro-Gly-Pro (ACTH 6-9 -PGP) peptide on the serum levels of pro- and anti-inflammatory cytokines in experimental...
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Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance
BackgroundDirofilaria immitis causes dirofilariosis, a potentially fatal condition in canids. Dirofilaria infections can be prevented with a...
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Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter
We studied the effect of nitric oxide (NO) on the functioning of P-glycoprotein transporter (Pgp) in Caco-2 cells. NO donor S-nitrosoglutathione...
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Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are available because the mechanisms underlying its...
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Architecture and connectivity of the human angular gyrus and of its homolog region in the macaque brain
The angular gyrus roughly corresponds to Brodmann’s area 39, which is a multimodal association brain region located in the posterior apex of the...
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The role of the angular gyrus in semantic cognition: a synthesis of five functional neuroimaging studies
Semantic knowledge is central to human cognition. The angular gyrus (AG) is widely considered a key brain region for semantic cognition. However, the...
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Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress
We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress. Semax was injected to Wistar male rats...
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Characterization of the angular gyrus in an older adult population: a multimodal multilevel approach
The angular gyrus (AG) has been associated with multiple cognitive functions, such as language, spatial and memory functions. Since the AG is thought...
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Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling
Variation in the efficacy and safety of central nervous system drugs between humans and rodents can be explained by physiological differences between...
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Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines
BackgroundIn vitro models based on brain capillary endothelial cells (BCECs) are among the most versatile tools in blood–brain barrier research for...
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Selective activations and functional connectivities to the sight of faces, scenes, body parts and tools in visual and non-visual cortical regions leading to the human hippocampus
Connectivity maps are now available for the 360 cortical regions in the Human Connectome Project Multimodal Parcellation atlas. Here we add function...
