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Promotion of aging heart function and its redox balance following hind-limb blood flow restriction plus endurance exercise training in rats: klotho and PGC1-α as involving candidate molecules
Mild to moderate-intensity endurance exercise training combined with hind-limb blood flow restriction (BFR) induces elderly heart rejuvenation and...
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A link between mitochondrial damage and the immune microenvironment of delayed onset muscle soreness
BackgroundDelayed onset muscle soreness (DOMS) is a self-healing muscle pain disorder. Inflammatory pain is the main feature of DOMS. More and more...
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PM2.5 Exposure Lowers Mitochondrial Endurance During Cardiac Recovery in a Rat Model of Myocardial Infarction
Many studies have reported the negative effect of PM 2.5 exposure on heart function which is likely to impair postcardiac surgery rehabilitation that...
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Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells
BackgroundIncreased mitochondrial activities contributing to cancer cell proliferation, invasion, and metastasis have been reported in different...
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Carcinoembryonic antigen potentiates non-small cell lung cancer progression via PKA-PGC-1ɑ axis
Carcinoembryonic antigen (CEA) is a tumor-associated antigen primarily produced by tumor cells. It has been implicated in various biological...
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The Protective Effects of Syringic Acid on Bisphenol A–Induced Neurotoxicity Possibly Through AMPK/PGC-1α/Fndc5 and CREB/BDNF Signaling Pathways
Bisphenol A (BPA), an endocrine disruptor, is commonly used to produce epoxy resins and polycarbonate plastics. Continuous exposure to BPA may...
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Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review
CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon tumor antigen stimulation, and then differentiate into...
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Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic Strategies
Neurodegenerative disorders (NDD) have grabbed significant scientific consideration due to their fast increase in prevalence worldwide. The specific...
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Acacetin alleviates energy metabolism disorder through promoting white fat browning mediated by AC-cAMP pathway
Acacetin (ACA), a flavone isolated from Chinese traditional medical herbs, has numerous pharmacological activities. However, little is known about...
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Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer’s Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways
Patients with Alzheimer's disease have increased risk of develo** heart disease, which therefore highlights the need for strategies aiming at...
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Exercise-induced cardiac mitochondrial reorganization and enhancement in spontaneously hypertensive rats
The myocardium is a highly oxidative tissue in which mitochondria are essential to supply the energy required to maintain pump function. When...
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Mitochondrial Function in Health and Disease: Responses to Helicobacter pylori Metabolism and Impact in Gastric Cancer Development
Mitochondria are major cellular organelles that play an essential role in metabolism, stress response, immunity, and cell fate. Mitochondria are...
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Treadmill running alleviates adipose tissue browning and lipolysis in rats with heart failure
This study observed the effects of treadmill running on adipose tissue browning and lipolysis in rats with induced heart failure and elucidated the...
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Targeting CAR T Cells’ Metabolic Pathways to Boost Their Effectiveness Against Tumors
Chimeric antigen receptor (CAR) T cells have shown decent therapeutic efficacy in treating hematologic cancers; however, their effectiveness has been...
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Integrated clinical and prognostic analyses of mTOR/Hippo pathway core genes in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most aggressive and dismal cancers globally. Emerging evidence has established that mTOR and Hippo...
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Iron Metabolism and Ferroptosis in Early Brain Injury after Subarachnoid Haemorrhage
At present, it appears that the prognosis for subarachnoid haemorrhage (SAH), which has a high death and disability rate, cannot be greatly improved...
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Renin-Angiotensin-Aldosterone System Role in Organ Fibrosis
The normal healing process secondary to injury, disease or toxins is a mandatory process to human life. The healing process begins with hemostasis,...
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Never in mitosis gene A-related kinase-6 deficiency deteriorates diabetic cardiomyopathy via regulating heat shock protein 72
AbstractNIMA (never in mitosis, gene A)-related kinase-6 (NEK6), a cell cycle regulatory gene, was found to regulate cardiac hypertrophy. However,...
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Biodistribution of Intravenously Transplanted Mitochondria Conjugated with Graphene Quantum Dots in Diabetic Rats
Mitochondria transplantation has emerged as a successful therapeutic modality to treat several degenerative diseases. However, the biodistribution of...
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Therapeutic Potential of PPARs in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most leading cause of dementia, characterized by the accumulation of amyloid beta (Aβ) plaques in the brain, leading...