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PDCD5 inhibits progression of renal cell carcinoma by promoting T cell immunity: with the involvement of the HDAC3/microRNA-195-5p/SGK1
BackgroundEpigenetics exerts a vital role in the onset and development of renal cell carcinoma (RCC). Mounting evidence has shed light on the...
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PDCD5 regulates iNKT cell terminal maturation and iNKT1 fate decision
Invariant natural killer T1 (iNKT1) cells are characterized by the preferential expression of T-box transcription factor T-bet (encoded by Tbx21 ) and...
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Drug Resistance in Hepatocellular Carcinoma
At present, the burden of cancer morbidity and mortality is increasing all over the world. Among all kinds of cancer, primary liver cancer is...
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Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma
BackgroundChaperonin-containing tailless complex polypeptide 1 (TCP1) subunit 3 (CCT3) has tumor-promoting effects in lung adenocarcinoma (LUAD)....
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Identification of cerebral spinal fluid protein biomarkers in Niemann-Pick disease, type C1
BackgroundNiemann-Pick disease, type C1 (NPC1) is an ultrarare, recessive, lethal, lysosomal disease characterized by progressive cerebellar ataxia...
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Deciphering p53 dynamics and cell fate in DNA damage response using mathematical modeling
The tumor suppressor p53 is activated in response to cellular stresses. The transcription factor p53 can activate the expression of numerous genes...
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Correction to: Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines
An amendment to this paper has been published and can be accessed via the original article.
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Epigenetics in Non-tumor Immune-Mediated Skin Diseases
Epigenetics is the study of the mechanisms that regulate gene expression without modifying DNA sequences. Knowledge of and evidence about how...
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Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
BackgroundMetastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important...
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The Immune System in Liver Cancer: From Beginning to Progression
Hepatocellular carcinoma is one of the deadliest cancers in the world; it is a disease that develops due to different etiologies. As a result of...
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Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction
BackgroundSexual dimorphism in placental physiology affects the functionality of placental adaptation during adverse pregnancy. Defects of placental...
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Potential Signature Therapeutic Biomarkers TOP2A, MAD2L1, and CDK1 in Colorectal Cancer: A Systems Biomedicine-Based Approach
Colorectal cancer is the third deadliest and fourth most diagnosed cancer. It is heterogeneously driven by varied mutations and mutagens, and thus,...
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Proteomic-miRNA Biomics Profile Reveals 2D Cultures of Human iPSC-Derived Neural Progenitor Cells More Sensitive than 3D Spheroid System Against the Experimental Exposure to Arsenic
The iPSC-derived 3D models are considered to be a connective link between 2D culture and in vivo studies. However, the sensitivity of such 3D models...
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Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses
Enterovirus 71 (EV71) is the major pathogens of human hand, foot, and mouth disease (HFMD). EV71 efficiently escapes innate immunity responses of the...
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Autophagy and Ischemic Stroke
Ischemic stroke refers to brain tissue ischemia, hypoxic necrosis, and brain softening caused by the interruption of the blood supply to the brain...
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The genomic regulation of metastatic dormancy
The genomics and pathways governing metastatic dormancy are critically important drivers of long-term patient survival given the considerable...
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Non-Coding RNAs and Neurodegenerative Diseases: Information of their Roles in Apoptosis
Apoptosis can be known as a key factor in the pathogenesis of neurodegenerative disorders. In disease conditions, the rate of apoptosis expands and...
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FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells
Apoptosis plays an important role in both carcinogenesis and cancer treatment. Understanding the mechanisms through which resistance to apoptosis...
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Epigenetics of Psoriasis
Psoriasis is a chronic and recurrent inflammatory skin disease, involving the rapid proliferation and abnormal differentiation of keratinocytes and...