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Pharmacology of Adenosine Receptors
Adenosine is an endogenous nucleoside molecule, regulating a myriad of physiological and pathological effects in almost all the organs systems...
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Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a deadly cancer worldwide, as a result of a late diagnosis and limited therapeutic options....
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Glial Cell Modulation of Dendritic Spine Structure and Synaptic Function
Glia comprise a heterogeneous group of cells involved in the structure and function of the central and peripheral nervous system. Glial cells are...
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Carica papaya: comprehensive overview of the nutritional values, phytochemicals and pharmacological activities
Carica papaya is a perennial large herbaceous plant known for diverse biological activities. Different parts of this plant such as seeds, leaves,...
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Resectable pancreatic adenocarcinoma neo-adjuvant FOLF(IRIN)OX-based chemotherapy - a multicenter, non-comparative, randomized, phase II trial (PANACHE01-PRODIGE48 study)
BackgroundAt time of diagnosis, less than 10% of patients with pancreatic adenocarcinomas (PDAC) are considered to be immediately operable (i.e....
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The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)
For over 40 years, the National Institute of Neurological Disorders and Stroke/National Institutes of Health-funded Anticonvulsant Screening Program...
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Synthesis, anticonvulsant activity, and molecular modeling studies of novel 1-phenyl/1-(4-chlorophenyl)-2-(1H-triazol-1-yl)ethanol ester derivatives
A series of new ester derivatives were synthesized by the reaction of various acids with 1-phenyl/1-(4-chlorophenyl)-2-(1 H -triazol-1-yl)ethanol and...
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The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond
The anticonvulsant screening program (ASP) of the national institute of neurological disorders and stroke (NINDS), National Institutes of Health has...
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Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs
The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. Except for some early...
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Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy
The successful identification of promising investigational therapies for the treatment of epilepsy can be credited to the use of numerous animal...
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Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP)
Cannabidiol (CBD) is a cannabinoid component of marijuana that has no significant activity at cannabinoid receptors or psychoactive effects. There is...
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Bridging the Gap in Neurotherapeutic Discovery and Development: The Role of the National Institute of Neurological Disorders and Stroke in Translational Neuroscience
The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous...
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Horned Owl, Snap** Turtle
In the late 1970s, as Koprowski’s third decade at Wistar began, life was good. The Koprowskis’ two sons were prospering. Claude had graduated from...
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Early High-Altitude Stations and Field Studies
It is convenient to use Paul Bert’s monumental book La Pression Barométrique (Bert, 1878) as a watershed separating early studies of...
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Sticky ends and a new Creation
James Watson in his book Recombinant DNA—A Short Course recalls that in 1966 despite the fact that the genetic code had been fully deciphered...
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Structure and Function of the Cerebellum: A Historical Introduction to Some Current Problems
This book is about the cerebellum; what it looks like, what it does, and how it does it. The central problem is to relate the unique structure and...