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HSP27 Modulates Neuropathic Pain by Inhibiting P2X3 Degradation
The role of heat shock protein 27 (HSP27), a chaperone, in neuropathic pain after nerve injury has not been systematically surveyed despite its...
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DT-0111: a novel P2X3 receptor antagonist
Extracellular adenosine 5’-triphosphate (ATP) acts as an autocrine and paracrine agent, the actions of which on affected cells are mediated by P2...
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Mass Balance and Metabolic Pathways of Eliapixant, a P2X3 Receptor Antagonist, in Healthy Male Volunteers
BackgroundOveractive adenosine triphosphate signaling via P2X3 homotrimeric receptors is implicated in multiple conditions. To fully understand the...
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A1 Adenosine Receptor Activation Inhibits P2X3 Receptor–Mediated ATP Currents in Rat Dorsal Root Ganglion Neurons
Purinergic signaling is involved in multiple pain processes. P2X3 receptor is a key target in pain therapeutics, while A1 adenosine receptor...
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Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia
Diabetic neuropathic pain (DNP) is frequent among patients with diabetes. We previously showed that P2X3 upregulation in dorsal root ganglia (DRG)...
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Preclinical and Clinical Pharmacokinetics and Bioavailability in Healthy Volunteers of a Novel Formulation of the Selective P2X3 Receptor Antagonist Eliapixant
Background and ObjectivesThe potent, selective P2X3 receptor antagonist eliapixant (BAY 1817080) is under development for conditions characterized by...
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Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor
Upregulation of P2X3 receptor (P2X3R) has been strongly implicated in nociceptive signaling including bone cancer pain (BCP). The present study,...
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SNI and CFA induce similar changes in TRPV1 and P2X3 expressions in the acute phase but not in the chronic phase of pain
Peripheral inflammation and nerve injury usually accompany each other. However, whether inflammatory and neuropathic pain share similar mechanisms at...
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P2X3 receptors contribute to transition from acute to chronic muscle pain
This study aimed to evaluate whether the development and/or maintenance of chronic-latent muscle hyperalgesia is modulated by P2X3 receptors. We also...
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Ganglion-Specific Sensitivity of P2X3 Receptors to Leu-Enkephalin
In this study, several properties of modulation of P2X3 currents by an endogenous opioid, leu-enkephalin (LEK), in neurons of the dorsal root and...
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P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain
Current therapies for the treatment of chronic pain provide inadequate relief for millions of suffering patients, demonstrating the need for better...
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Electroacupuncture alleviates diabetic neuropathic pain in rats by suppressing P2X3 receptor expression in dorsal root ganglia
Diabetic neuropathic pain (DNP) is a troublesome diabetes complication all over the world. P2X3 receptor (P2X3R), a purinergic receptor from dorsal...
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Blockage of HCN Channels Inhibits the Function of P2X Receptors in Rat Dorsal Root Ganglion Neurons
Hyperpolarization-activated cyclic nucleotide-gated channels and purinergic P2X receptors play critical roles in the nerve injury-induced pain...
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Development of Purinergic Receptor Agonists and Antagonists
Adenosine, P2Y, and P2X receptors have been the focus of purinergic ligand development in the pharmaceutical sector and academic medicinal chemistry...
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ATP, an attractive target for the treatment of refractory chronic cough
Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common...
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P2X3 receptors contribute to muscle pain induced by static contraction by a mechanism dependent on neutrophil migration
P2X3 receptors are involved with several pain conditions. Muscle pain induced by static contraction has an important socioeconomic impact. Here, we...
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The Role of ATP and Purinergic Receptors in Taste Signaling
This review summarizes our understanding of ATP signaling in taste and describes new directions for research. ATP meets all requisite criteria to be...
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Correction to: lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia
In the original version of this article “lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root...
