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Antimicrobial resistance survey and whole-genome analysis of nosocomial P. Aeruginosa isolated from eastern Province of China in 2016–2021
BackgroundPseudomonas aeruginosa is a major Gram-negative pathogen that can exacerbate lung infections in the patients with cystic fibrosis, which...
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Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
PurposeDespite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of relapsed/refractory B...
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AATF Competitively Interacts with Nuclear AIF and Inhibits Parthanatos of Neurons in dMCAO/R and OGD/R Models
Ischemic stroke (IS) poses a heavy burden on the healthcare system, and revascularization is the most effective treatment. However,...
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P
See Perception and Attention Deficit Model.
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Temporal trend in hospitalizations for malignant neoplasm and benign neoplasm: a nationwide study, China, 2004–2020
The increasing cancer burden calls for reliably assessed changes in the hospitalizations for tumors over time and space in China. This study...
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Naturally selected CD7 CAR-T therapy without genetic editing demonstrates significant antitumour efficacy against relapsed and refractory acute myeloid leukaemia (R/R-AML)
BackgroundThe survival rate for patients with relapsed and refractory acute myeloid leukaemia (R/R-AML) remains poor, and treatment is challenging....
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Associations between experience of stressful life events and cancer prevalence in China: results from the China Kadoorie Biobank study
BackgroundStudies examining the relationships of stressful life events and cancer yielded inconsistent findings, while relevant evidence in mainland...
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Assessing colposcopy competencies in medically underserved communities: a multi-center study in China
BackgroundColposcopy plays an essential role in diagnosing cervical lesions and directing biopsy; however, there are few studies of the capabilities...
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Clinical characteristics and outcomes of newly diagnosed patients with human immunodeficiency virus-associated Burkitt lymphoma: the Central and Western China AIDS lymphoma league 002 study (CALL-002 study)
BackgroundDespite the introduction of combined antiretroviral therapy, the clinical outcomes of HIV-associated Burkitt lymphoma (BL) remain poor.
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The prevalence of canine dirofilariasis in China: a systematic review and meta-analysis
BackgroundDirofilariasis, the disease caused by Dirofilaria spp., and in particular by Dirofilaria immitis and Dirofilaria repens in canines, occurs...
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Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form...
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A genomic variation map provides insights into peanut diversity in China and associations with 28 agronomic traits
Peanut ( Arachis hypogaea L.) is an important allotetraploid oil and food legume crop. China is one of the world’s largest peanut producers and...
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Molecular epidemiological and genetic characterization of pseudorabies virus in Guangxi, China
Pseudorabies virus (PRV) is an important pathogen that can cause harm to the pig population. Since 2011, there have been a number of large-scale...
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Aberrant R-loop–mediated immune evasion, cellular communication, and metabolic reprogramming affect cancer progression: a single-cell analysis
Dysregulation of R-loop homeostasis is closely related to various human diseases, including cancer. However, the causality of aberrant R-loops in...
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Real-world implementation of a multilevel interventions program to prevent mother-to-child transmission of HBV in China
Reducing hepatitis B virus (HBV) mother-to-child transmission (MTCT) is a fundamental step toward the HBV elimination goal. The multicentred,...
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Epstein-Barr virus variation in people living with human immunodeficiency virus in southeastern China
BackgroundPatients infected with HIV are at high risk of develo** Epstein-Barr Virus (EBV)-related diseases. The genotype and viral biological...
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Reassortment and genomic analysis of a G9P[8]-E2 rotavirus isolated in China
ObjectiveTo isolate a prevalent G9P[8] group A rotavirus (RVA) (N4006) in China and investigate its genomic and evolutionary characteristics, with...
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Genomic epidemiology of CVA10 in Guangdong, China, 2013–2021
Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness primarily affecting children globally. A significant epidemiological...
