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Post-Infectious Bladder Hypersensitivity in the Development of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
The bladder is innervated by a complex network of afferent nerves that project into the spinal cord, providing sensory input to the central nervous...
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Interstitial Cystitis/Bladder Pain Syndrome
Painful bladder syndrome or interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic debilitating disease, defined by a variable combination...
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Feasibility and safety of laparoscopic radical cystectomy for male octogenarians with muscle-invasive bladder cancer
This study was designed to evaluate the safety and feasibility of laparoscopic radical cystectomy (LRC) for male octogenarian patients with...
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PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents
Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) cells upon bladder distension attenuates spontaneous phasic...
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Role of PTHrP in attenuating transient pressure rises and associated afferent nerve activity of the rat bladder
Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) as the bladder fills acts as an endogenous DSM relaxant to...
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Effect of GR205171 on autonomic dysreflexia induced by colorectal distension in spinal cord injured rats
Study designPreclinical pharmacology.
ObjectivesTo determine whether blocking substance P signaling attenuates the hypertension and bradycardia...
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The urothelium: a multi-faceted barrier against a harsh environment
All mucosal surfaces must deal with the challenge of exposure to the outside world. The urothelium is a highly specialized layer of stratified...
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Hypersensitivity of bladder low threshold, wide dynamic range, afferent fibres following treatment with the chemotherapeutic drugs cyclophosphamide and ifosfamide
The cytotoxic drugs cyclophosphamide (CPO) and ifosfamide (IFO) cause toxic urological effects due to the production of urinary metabolites that...
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Erosion of urethra by malleable penile prosthesis in a spinal cord injury patient with diabetes mellitus and repeated misplacement of Foley balloon in the urethra: lessons we learn: a case report
IntroductionSpinal cord injury patients with indwelling urethral catheters are at high risk for erosion of urethra by penile prosthesis. Repeated...
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Iatrogenic bladder rupture in individuals with disability related to spinal cord injury and chronic indwelling urethral catheters
IntroductionBladder rupture in patients with indwelling urethral catheters is rare. Herein, we describe two spinal cord injured (SCI) patients with...
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Spinal Afferent Innervation of the Uterus
The extrinsic neural innervation of the uterus plays an important role in modulating uterine functions that are critical to reproductive success. Its...
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Ultrasound of the Urinary System
Our kidneys help preserve our homeostasis. To do so, they filter our blood at a high rate, approximately 140 liters a day. However, they expel the...
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The Management of Neurological Symptoms in Palliative Care
Neurological disease is a major cause of disability and death across the world. There is increasing evidence that palliative care is effective in...
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Barriers and facilitators to optimising inpatient bladder management after spinal cord injury
Study designQualitative survey.
ObjectivesExamine clinicians’ perspectives on adherence to published evidence-based guidelines and...
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Pre-clinical Models of Endometriosis: A Focus on Chronic Pain
Endometriosis is a multifaceted chronic disease with a complex and variable display of clinical symptoms. Chronic pelvic pain (CPP) affects most...
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Enteric Control of the Sympathetic Nervous System
The autonomic nervous system that regulates the gut is divided into sympathetic (SNS), parasympathetic (PNS), and enteric nervous systems (ENS). They...
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Advancing the treatment of localized prostate cancer with MR-guided radiotherapy
External beam radiotherapy (EBRT) is an important cornerstone in the treatment of localized prostate cancer. Current image-guided radiotherapy (IGRT)...
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Botulinum Toxin Therapy for Pelvic and Urogenital Pain
In female pelvic pain, one double, placebo-controlled study (Class II) has shown significant improvement of pelvic pain after injection of...
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The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present
Hydrogen sulfide (H 2 S) is known as a chemical gas in nature with both enzymatic and non-enzymatic biosynthesis in different human organs. A couple of...
