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Causal relationship between thyroid dysfunction and ovarian cancer: a two-sample Mendelian randomization study
PurposeObservational studies and clinical validation have suggested a link between thyroid dysfunction and an elevated ovarian cancer (OC) risk....
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Menopausal hormone therapy use and risk of ovarian cancer by race: the ovarian cancer in women of African ancestry consortium
BackgroundMost studies examining post-menopausal menopausal hormone therapy (MHT) use and ovarian cancer risk have focused on White women and few...
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Engineering Approaches in Ovarian Cancer Cell Culture
Determination of the frequency of somatic mutations, copy number variations, and the composition of single-nucleus transcriptomes in epithelial...
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Cancer-Associated Fibroblast-Related Genes Are Associated with Prognosis of Patients with Ovarian Cancer
AbstractThis study aimed to investigate the effects of cancer-associated fibroblasts (CAFs)-related genes on prognosis and immunity in ovarian...
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An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids
BackgroundOvarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are...
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Vitamin D status during and after treatment and ovarian cancer survival
PurposeFive-year relative survival for ovarian cancer remains below 50%. Strategies to improve outcomes are needed. Higher serum 25-hydroxyvitamin D...
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HADHA promotes ovarian cancer outgrowth via up-regulating CDK1
BackgroundOvarian cancer, a prevalent cause of cancer-related mortality among gynecological cancers, still lacks a clear understanding of its...
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Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by inhibiting glutathione synthesis
Ovarian cancer is a malignant tumor originating from the ovary, characterized by its high mortality rate and propensity for recurrence. In some...
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miR-3653-3p Expression in PBMCs: Unveiling the Diagnostic Potential for Ovarian Cancer
Ovarian cancer is typically diagnosed at an advanced stage, recurs early and often, and currently lacks effective treatment. Therefore, overall...
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CSGALNACT2 restricts ovarian cancer migration and invasion by modulating MAPK/ERK pathway through DUSP1
PurposeOvarian cancer is one of the leading causes of cancer-related death among women. CSGALNACT2 is a vital Golgi transferase and is related to a...
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Germline mutations in BRCA1 and BRCA2 among Brazilian women with ovarian cancer treated in the Public Health System
BackgroundGermline mutations in BRCA1 and BRCA2 genes are among the main causes of hereditary ovarian cancer. Identifying these mutations may reduce...
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Molecular Characterization of Single Circulating Tumor Cells in Breast and Ovarian Cancer
Epithelial ovarian cancer (EOC)Epithelial ovarian cancer (EOC) still has the highest mortality rate of all gynecological malignancies, diagnosed...
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ST14 interacts with TMEFF1 and is a predictor of poor prognosis in ovarian cancer
TMEFF1 is a new protein involved in the physiological functions of the central nervous system, and we previously reported TMEFF1 can promote ovarian...
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Low-dose aspirin use and risk of ovarian cancer: a combined analysis from two nationwide studies in Denmark and Sweden
BackgroundStudies on association between low-dose aspirin use and ovarian cancer risk were mostly based on self-reported medication use and few had...
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Ligand-based adoptive T cell targeting CA125 in ovarian cancer
BackgroundOvarian cancer (OC) is a highly aggressive gynecological malignancy prevalent worldwide. Most OC cases are typically diagnosed at advanced...
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PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway
BackgroundOvarian cancer is commonly associated with a poor prognosis due to metastasis and chemoresistance. PINK1 (PTEN-induced kinase 1) is a...
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Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer
BackgroundOvarian cancer (OC) is characterized by its rapid growth and spread which, accompanied by a low 5-year survival rate, necessitates the...
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Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as maintenance therapy after first-line chemotherapy have improved progression-free...
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RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells
Ovarian cancer is the leading cause of death from gynecologic illnesses worldwide. High-grade serous ovarian cancer (HGSOC) is a gynecological tumor...
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Correlation of clinicopathological and prognostic characteristics between endometriosis-associated and primary ovarian cancer
BackgroundThe main aim of this study was to establish the clinicopathological and prognostic correlations between endometriosis-associated and...
