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OCT4’s role and mechanism underlying oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative...
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Squamous Cell Carcinoma Predisposition Pathophysiology, Diagnosis, and Treatment
Squamous Cell Carcinoma (SCC) is a prevalent form of skin and oral cancer, characterized by the uncontrolled growth of abnormal squamous cells in the...
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Molecular Carcinopathogenesis in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is a heterogeneous and multifactorial disease with generally an aggressive behavior. The molecular carcinogenesis...
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RAD51 is a poor prognostic marker and a potential therapeutic target for oral squamous cell carcinoma
ObjectivesRAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role...
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MicroRNA-191 regulates oral squamous cell carcinoma cells growth by targeting PLCD1 via the Wnt/β-catenin signaling pathway
BackgroundStudies have shown that microRNA-191 (miR-191) is involved in the development and progression of a variety of tumors. However, the function...
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Diagnostic accuracy of intraoperative frozen section for margin evaluation of oral cavity squamous cell carcinoma
ObjectivesIntraoperative frozen-section evaluation is a valuable technique for detecting positive margins intraoperatively for oral squamous cell...
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Analysis of the effect of CCR7 on the microenvironment of mouse oral squamous cell carcinoma by single-cell RNA sequencing technology
BackgroundStudies have shown that CCR7, an important inflammatory factor, can promote the proliferation and metastasis of oral squamous cell...
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Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells
BackgroundOral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent...
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TCL1A-expressing B cells are critical for tertiary lymphoid structure formation and the prognosis of oral squamous cell carcinoma
BackgroundOral squamous cell carcinoma (OSCC) is a malignant tumor with a poor prognosis. Traditional treatments have limited effectiveness....
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Comparative proteomics of oral squamous cell carcinoma tissue in consumers and non-consumers of tobacco
BackgroundTobacco is a risk factor for oral squamous cell carcinoma (OSCC). Some cases of OSCC occur without any known cause and is called idiopathic...
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Fungi: Culprits or Bystanders in Oral Squamous Cell Carcinoma
Fungi are mainly saprophytic organisms but can be implicated as a causative factor for certain diseases. Of late, various fungi have also been found...
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Viral-Induced Carcinopathogenesis in Oral Squamous Cell Carcinoma
Oral cancer is multifactorial in etiology with tobacco being the most associated etiological factor. A fraction of oral cancers are associated with...
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Squamous Cell Carcinoma Predisposition Pathophysiology, Diagnosis, and Treatment
Squamous Cell Carcinoma (SCC) is a prevalent form of skin and oral cancer, characterized by the uncontrolled growth of abnormal squamous cells in the...
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Comparative clinical significance and biological roles of PFKFB family members in oral squamous cell carcinoma
BackgroundCancer cells promote glycolysis, which supports rapid cell growth and proliferation. Phosphofructokinase-fructose bisphosphatases (PFKFBs),...
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MFI2 upregulation promotes malignant progression through EGF/FAK signaling in oral cavity squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is the predominant histological type of the head and neck squamous cell carcinoma (HNSCC). By comparing the...
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Reactive Oxygen Species in Oral Squamous Cell Carcinoma Progression and Importance of Stem Cells in Cancer Therapeutics
Oral squamous cell carcinoma is the most frequent oral malignancy worldwide classified under the head and neck cancer category. Reactive oxygen...
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Reactive Oxygen Species in Oral Squamous Cell Carcinoma Progression and Importance of Stem Cells in Cancer Therapeutics
Oral squamous cell carcinoma is the most frequent oral malignancy worldwide classified under the head and neck cancer category. Reactive oxygen...
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Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
Accumulating evidence indicates that the disulfiram/copper complex (DSF/Cu) has been shown to have potent antitumor activity against various cancers....
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WNT3 promotes chemoresistance to 5-Fluorouracil in oral squamous cell carcinoma via activating the canonical β-catenin pathway
Background5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of...
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Role of Inflammation and Infection in Oral Squamous Cell Carcinoma
Putative etiological association of various microbial infections with oral squamous cell carcinoma is gaining attention in research work. Various...