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Nano-optogenetic CAR-T Cell Immunotherapy
Chimeric antigen receptor (CAR)-T cell immunotherapy emerges as an effective cancer treatment. However, significant safety concerns remain, such as...
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Optogenetic and High-Throughput Drug Discovery
Optogenetics, a technique based on natural or genetically engineered light-sensitive proteins, combines genetic manipulation and optics offering...
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Optogenetic Approach in Trigeminal Neuralgia and Potential Concerns: Preclinical Insights
The integration of optogenetics in the trigeminal pain circuitry broadens and reinforces existing pain investigations. Similar to research on spinal...
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Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
BackgroundAlzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye...
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Neuron type-specific optogenetic stimulation for differential stroke recovery in chronic capsular infarct
Cortical neuromodulation (CNM) is widely used to promote recovery after stroke. Despite the beneficial results of CNM, the roles played by different...
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Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications
Animal opsins are light activated G-protein-coupled receptors, capable of optogenetic control of G-protein signalling for research or therapeutic...
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Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES
Optogenetic actuators are rapidly advancing tools used to control physiology in excitable cells, such as neurons and cardiomyocytes. In neuroscience,...
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Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity map**
BackgroundCortical spreading depression (CSD) is an electrophysiological event underlying migraine aura. Traditional CSD models are invasive and...
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Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called temporal association learning. The...
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Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain
Chronic pain relief remains an unmet medical need. Current research points to a substantial contribution of glia-neuron interaction in its...
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Optogenetic stimulation of vagal nerves for enhanced glucose-stimulated insulin secretion and β cell proliferation
The enhancement of insulin secretion and of the proliferation of pancreatic β cells are promising therapeutic options for diabetes. Signals from the...
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Examining the low-voltage fast seizure-onset and its response to optogenetic stimulation in a biophysical network model of the hippocampus
Low-voltage fast (LVF) seizure-onset is one of the two frequently observed temporal lobe seizure-onset patterns. Depth electroencephalogram profile...
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Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-ION Rat
In individuals with chronic neuropathic pain, the posterior insular cortex (PIC) has been found to exhibit increased glutamatergic activity, and the...
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Closed-loop optogenetic control of the dynamics of neural activity in non-human primates
Electrical neurostimulation is effective in the treatment of neurological disorders, but associated recording artefacts generally limit its...
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Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice
BackgroundNeuroinflammation has been identified as one of the primary pathogenic factors of neuropsychiatric systemic lupus erythematosus (NPSLE)....
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Optogenetic Animal Models of Depression: From Mice to Men
Optogenetics, the light-induced reversible control of specific neuronal ensembles, has revolutionized the circuit level analysis of depression,...
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Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as...
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Model-based optogenetic stimulation to regulate beta oscillations in Parkinsonian neural networks
Optogenetic stimulation, an effective stimulation technique, is applied to the treatment of Parkinson’s disease (PD) to compete with the current...
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