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Optimal design of synthetic circular RNAs
Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently linked via back-splicing. Due to their versatility, the need to...
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A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK
Inhibiting MerTK on macrophages is a promising therapeutic strategy for augmenting anti-tumor immunity. However, blocking MerTK on retinal pigment...
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Enhanced Optimal Parameter-Based Nebulizer Design for Flow Analysis of Fluticasone Propionate
A jet nebulizer sprays a fine mist or aerosol directly into the lungs to reduce inflammation, expand airways, and make breathing easier for...
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pH Switchable LLC Nanoparticles Targeting Colon: Optimization Using D-Optimal Design
PurposeTo design pH switchable LLC (lyotropic liquid crystal) nanoparticles with the goal of exclusively delivering 5-Fluorouracil (5-FU) in the...
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Exploiting response surface D-optimal design study for preparation and optimization of spanlastics loaded with miconazole nitrate as a model antifungal drug for topical application
PurposeSkin fungal infections are widely spreading worldwide and are considered a main cause of skin, mucous membranes, and systemic diseases. In an...
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Surface Engineering and Optimizing DepoFoam System: A Robust Quality by Design Approach for Optimal Drug Delivery, Stability, and Quality
PurposeThe study utilized non-ionic polymer macrogol to transform the surface properties of the DepoFoam drug carrier system, develo**...
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Optimal sample selection applied to information rich, dense data
Dense data can be classified into superdense information-poor data (type 1 dense data) and dense information-rich data (type 2 dense data)....
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Defining the balance between optimal immunity and immunopathology in influenza virus infection
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss our current understanding...
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Design considerations for patient-specific bone fixation plates: a literature review
In orthopedic surgery, patient-specific bone plates are used for fixation when conventional bone plates do not fit the specific anatomy of a patient....
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A multidomain lifestyle intervention to maintain optimal cognitive functioning in Dutch older adults—study design and baseline characteristics of the FINGER-NL randomized controlled trial
BackgroundEvidence on the effectiveness of multidomain lifestyle interventions to prevent cognitive decline in older people without dementia is...
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Design and Evaluation of Ginkgolides Gastric Floating Controlled Release Tablets Based on Solid Supersaturated Self-nanoemulsifying
Ginkgolides are receptor antagonist of platelet activating factor with great clinical prospect, but its application is limited by its low solubility,...
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Microwave-assisted drying of Prasakanphlu herbal granules and formulation development of Prasakanphlu tablets: Design of Experiments approach
This work aimed to apply the Design of Experiments (DOE) approach in microwave-assisted drying of Prasakanphlu (PSKP) herbal granules. Furthermore,...
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CFI: a VR motor rehabilitation serious game design framework integrating rehabilitation function and game design principles with an upper limb case
Virtual reality (VR) Rehabilitation holds the potential to address the challenge that patients feel bored and give up long-term rehabilitation...
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Material design for oral insulin delivery
Frequent insulin injections remain the primary method for controlling the blood glucose level of individuals with diabetes mellitus but are...
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Optimal global spending for group A Streptococcus vaccine research and development
Group A Streptococcus (Strep A) leads to 600,000 deaths and 600 million cases of pharyngitis annually. Although long a promising target for vaccine...
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Microfluidic design for in-vitro liver zonation—a numerical analysis using COMSOL Multiphysics
The liver is one of the most important organs, with a complex physiology. Current in-vitro approaches are not accurate for disease modeling and drug...
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Virtual Planning and Patient-Specific Graft Design for Aortic Repairs
PurposePatients presenting with coarctation of the aorta (CoA) may also suffer from co-existing transverse arch hypoplasia (TAH). Depending on the...
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Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly develo** field in which the delivery of genetic information in the form of mRNA is used to direct therapeutic...
