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1. Molecular Mechanisms of Oncogenesis

   Oncogenesis is the process of transformation of normal cells into malignant cells. It is often initiated by a variety of exogenous environmental and...

   Kanika Thakur, Shtakshi Sharma, ... Ravinder Kumar in Molecular Biomarkers for Cancer Diagnosis and Therapy

   Chapter 2024
   

2. Mechanisms of Oncogenesis

   Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...

   Kamlesh Guleria, Vasudha Sambyal in Handbook of Oncobiology: From Basic to Clinical Sciences

   Reference work entry 2024
   

3. Mechanisms of Oncogenesis

   Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...

   Kamlesh Guleria, Vasudha Sambyal in Handbook of Oncobiology: From Basic to Clinical Sciences

   Living reference work entry 2023
   

4. TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

   The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human...

   Estelle Balducci, Thomas Steimlé, ... Vahid Asnafi in Molecular Cancer

   Article Open access 10 July 2023
   

5. Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis

   Purpose

   Managing high-grade endometrial cancer in Martinique poses significant challenges. The diversity of copy number alterations in high-grade...

   Regine Marlin, Jean-Samuel Loger, ... Mehdi Jean-Laurent in Cellular Oncology

   Article Open access 02 April 2024
   

6. Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma

   Background

   Extranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A better understanding...

   Jianbiao Zhou, Sabrina Hui-Min Toh, ... Wee-Joo Chng in Molecular Cancer

   Article Open access 10 April 2023
   

7. A novel upregulated hsa_circ_0032746 regulates the oncogenesis of esophageal squamous cell carcinoma by regulating miR-4270/MCM3 axis

   Introduction

   Circular RNAs (CircRNA) have emerged as an interest of research in recent years due to its regulatory role in various kinds of cancers of...

   Sachin Mulmi Shrestha, **n Fang, ... Ruihua Shi in Human Genomics

   Article Open access 10 January 2024
   

8. Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis

   Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of...

   Tarang Sharma, Ashna Gupta, ... Shahab Uddin in Cancer and Metastasis Reviews

   Article Open access 05 May 2022
   

9. Ablation of the sperm-associated antigen 11A (SPAG11A) protein by active immunization promotes epididymal oncogenesis in the rat

   Incidence of cancer in the epididymis is very rare. It is proposed that proteins specific to this organ may contribute to this unique property. We...

   Kumari Sangeeta, Suresh Yenugu in Cell and Tissue Research

   Article 19 April 2022
   

10. The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities

    Glioma is the most common and lethal intrinsic primary tumor of the brain. Its controversial origins may contribute to its heterogeneity, creating...

    Qiyuan Zhuang, Hui Yang, Ying Mao in Neuroscience Bulletin

    Article Open access 13 October 2022
    

11. Recent knowledge of NFATc4 in oncogenesis and cancer prognosis

    Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca ²⁺ /calcineurin signaling....

    Qiu-Hua Zhong, Si-Wei Zha, ... Yan-Ming Xu in Cancer Cell International

    Article Open access 13 June 2022
    

12. Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade

    Background

    To investigate the potential role of Long Non-coding RNAs (lncRNAs) in the progression of osteosarcoma.

    Methods

    The candidate lncRNAs were...

    Shiyuan Li, Ming Zeng, ... Jiaying Li in BMC Cancer

    Article Open access 05 October 2022
    

13. The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration

    Osteosarcoma is an aggressive malignant bone sarcoma worldwide. A causal gene network with specific functions underlying both the development and...

    Jiahua Li, Hui Shi, ... Ming Lu in BMC Cancer

    Article Open access 25 January 2022
    

14. Signaling pathways of EBV-induced oncogenesis

    Epstein-Barr virus (EBV) is closely associated with multiple human cancers. EBV-associated cancers are mainly lymphomas derived from B cells and T...

    Yin Luo, Yitong Liu, ... Runliang Gan in Cancer Cell International

    Article Open access 06 February 2021
    

15. Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma

    Background

    Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC)....

    Fei Li, Wenzhe Si, ... Rui Wei in Molecular Cancer

    Article Open access 06 May 2024
    

16. NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression

    Background

    Numerous common oncogenic driver events have been confirmed in non-small cell lung cancer (NSCLC). Although targeted therapy has...

    Huanhuan Sun, Hong Zhang, ... Haiqing Ma in Molecular Cancer

    Article Open access 18 February 2022
    

17. Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis

    Background

    Long-term environmental exposure to metals leads to epigenetic changes and may increase risks to human health. The relationship between the...

    Ani Stepanyan, Anna Petrackova, ... Arsen Arakelyan in Clinical Epigenetics

    Article Open access 07 August 2023
    

18. The KRAS^G12D inhibitor MRTX1133 elucidates KRAS-mediated oncogenesis

    in Nature Medicine

    Article 07 October 2022
    

19. The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis

    Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated...

    J. Charostad, M. Nakhaie, ... E. Faghihloo in Infectious Agents and Cancer

    Article Open access 15 October 2020
    

20. Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer

    Background

    NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and...

    Tie Xu, Yulan Zeng, ... Shuangbing Xu in Journal of Experimental & Clinical Cancer Research

    Article Open access 10 September 2020