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CDK5: an oncogene or an anti-oncogene: location location location
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in...
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Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment
Immune checkpoint inhibitors (ICIs) have revolutionized the clinical management of multiple tumours. However, only a few patients respond to ICIs,...
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Proto-oncogene mutations in middle ear cholesteatoma contribute to its pathogenesis
BackgroundChronic inflammation causes bone destruction in middle ear cholesteatomas (MECs). However, the causes of their neoplastic features remain...
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BCLAF1 is Expressed as a Potential Anti-oncogene in Bile Duct Cancer
Validating the role of BCLAF1 in the development of Bile Duct Cancer. Differential expression of BCLAF1 in Bile Duct Cancer and normal tissues was...
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ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors
BackgroundATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a...
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IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
BackgroundNeuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of...
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Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma
The biological functions of noncoding RNA N 6 -methyladenosine (m 6 A) modification remain poorly understood. In the present study, we depict the...
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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms
Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms....
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TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence
ERG translocations are commonly involved in the initiation of prostate neoplasia, yet previous experimental approaches have not addressed mechanisms...
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AIP: A double agent? The tissue-specific role of AIP as a tumour suppressor or as an oncogene
Aryl hydrocarbon receptor-interacting protein (AIP) is a co-chaperone to heat shock proteins and nuclear receptors. Loss-of-function heterozygote...
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Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer
RNA methylation modifications, especially m6A mRNA modification, are known to be extensively involved in tumor development. However, the relationship...
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Long non-coding RNA XIST: a novel oncogene in multiple cancers
Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally...
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GNA13 suppresses proliferation of ER+ breast cancer cells via ERα dependent upregulation of the MYC oncogene
GNA13 (Gα13) is one of two alpha subunit members of the G12/13 family of heterotrimeric G-proteins which mediate signaling downstream of GPCRs. It is...
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Creatine Kinase-MM/Proto-oncogene Tyrosine-Protein Kinase Receptor as a Sensitive Indicator for Duchenne Muscular Dystrophy Carriers
Duchenne muscular dystrophy (DMD), a lethal X-linked recessive genetic disease, is characterized by progressive muscle wasting which will lead to...
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Identifying Genetic Signatures Associated with Oncogene-Induced Replication Stress in Osteosarcoma and Screening for Potential Targeted Drugs
Osteosarcoma is the most common type of primary malignant bone tumor. Due to the lack of selectivity and sensitivity of chemotherapy drugs to tumor...
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Oncogene-mediated metabolic gene signature predicts breast cancer outcome
Breast cancer remains the second most lethal cancer among women in the United States and triple-negative breast cancer is the most aggressive subtype...
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Oncogene SCARNA12 as a potential diagnostic biomarker for colorectal cancer
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, and represents a severe threat to the life and health of...
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Plectin promotes tumor formation by B16 mouse melanoma cells via regulation of Rous sarcoma oncogene activity
BackgroundMelanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the...
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Chromothripsis followed by circular recombination drives oncogene amplification in human cancer
The mechanisms behind the evolution of complex genomic amplifications in cancer have remained largely unclear. Using whole-genome sequencing data of...
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Inhibition of MER proto-oncogene tyrosine kinase by an antisense oligonucleotide enhances treatment efficacy of immunoradiotherapy
BackgroundThe combination of radiotherapy and immunotherapy (immunoradiotherapy) has been increasingly used for treating a wide range of cancers....
