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Development of a Once-Daily Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772 using DiffCORE Technology
PurposeGSK2982772 is a selective inhibitor of receptor-interacting protein kinase-1 (RIPK1) with a short 2- to 3-h half-life. In a previous...
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Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772
PurposeGSK2982772 is a selective inhibitor of receptor-interacting protein kinase-1, with a 2–3 h half-life. This study evaluated if a once-daily...
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Once-daily 1 g ceftriaxone optimizes exposure in patients with septic shock and hypoalbuminemia receiving continuous veno-venous hemodiafiltration
PurposeCeftriaxone total and unbound pharmacokinetics (PK) can be altered in critically ill patients with septic shock and hypoalbuminemia receiving...
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Daily versus alternate day oral iron therapy in iron deficiency anemia: a systematic review
Daily administration of oral iron is considered the current treatment standard for treating iron deficiency anemia due to availability and reduced...
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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis
Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is achieved. We show here that Drosophila glia exhibit a...
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Real world clinical experience using daily intelligence-assisted online adaptive radiotherapy for head and neck cancer
BackgroundAdaptive radiation therapy (ART) offers a dynamic approach to address structural and spatial changes that occur during radiotherapy (RT)...
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Incorporating Mindfulness Practice for Better Performance in Work and Daily Life
MindfulnessMindfulness practicesPractice have reached the mainstream in the last decades. From senior executives of big companies to athletes, actors...
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Clinical efficacy and bleeding outcomes of tissue plasminogen activator and dornase alfa in pleural space infection with once daily concurrent administration: a retrospective cohort study
ObjectiveThe use of intrapleural tissue plasminogen activator (tPA) and dornase alfa (DNase) is common in the management of pleural space infection....
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Wearable full-body motion tracking of activities of daily living predicts disease trajectory in Duchenne muscular dystrophy
Artificial intelligence has the potential to revolutionize healthcare, yet clinical trials in neurological diseases continue to rely on subjective,...
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Convolution-based approach for modeling the paliperidone extended release and Long-Acting Injectable (LAI) PK of once-, and three-monthly products administration and for optimizing the development of new LAI products
The aim of this paper was to develop a convolution-based modeling approach for describing the paliperidone PK resulting from the administration of...
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Comparison of three doses of amikacin on alternate days with a daily dose of meropenem during the same period for the treatment of urinary tract infection with E. coli: a double-blind clinical trial
ObjectivesUrinary tract infections (UTIs) are very common infections in humans, and Escherichia coli ( E. coli ) is the commonest pathogen leading to...
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Predicting patient-reported outcome of activities of daily living in stroke rehabilitation: a machine learning study
BackgroundMachine Learning is increasingly used to predict rehabilitation outcomes in stroke in the context of precision rehabilitation and...
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Optimal fractionation and timing of weekly cone-beam CT in daily surface-guided radiotherapy for breast cancer
PurposeSurface-guided radiotherapy (SGRT) has been demonstrated to be a promising supplement to cone-beam computed tomography (CBCT) in adjuvant...
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Risk thresholds for patients to switch between daily tablets and biweekly infusions in second-line treatment for advanced hepatocellular carcinoma: a patient preference study
BackgroundHistorically, high hepatocellular carcinoma (HCC)–related mortality has been, in part, due to lack of effective therapies; however, several...
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Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients
BackgroundProteasome inhibitors (PIs), including carfilzomib, potentiate the activity of selinexor, a novel, first-in-class, oral selective inhibitor...
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Toxicity of a novel antifungal agent (ATB1651 gel) in Yucatan minipigs (Sus scrofa) following 4 weeks of daily dermal administration
ATB1651 gel is an antifungal drug candidate that enhances antifungal activity through substitution of several aryl rings, alkyl chains, and methyl...
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Diagnostic performance of automated, streamlined, daily updated exome analysis in patients with neurodevelopmental delay
BackgroundThe diagnostic yield of whole-exome sequencing (WES) varies from 30%–50% among patients with mild to severe neurodevelopmental delay...
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Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration
Background and ObjectiveThere are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased...
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Hybrid brain/neural interface and autonomous vision-guided whole-arm exoskeleton control to perform activities of daily living (ADLs)
BackgroundThe aging of the population and the progressive increase of life expectancy in developed countries is leading to a high incidence of...
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Go beyond the limits of genetic algorithm in daily covariate selection practice
Covariate identification is an important step in the development of a population pharmacokinetic/pharmacodynamic model. Among the different available...
