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In Vitro Inhibitory Effects and Bioinformatic Analysis of Norfloxacin and Ofloxacin on Piroplasm
PurposeThe in vitro inhibitory effect of two fluroquinolone antibiotics, norfloxacin and ofloxacin, was evaluated in this study on the growth of...
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RETRACTED ARTICLE: Ofloxacin-Loaded Niosome-Laden Contact Lens: Improved Properties of Biomaterial for Ocular Drug Delivery
Currently, bacterial conjunctivitis is managed by multiple antibiotic eye-drop solution, which is highly inefficient due to low ocular...
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Promising bioadhesive ofloxacin-loaded polymeric nanoparticles for the treatment of ocular inflammation: formulation and in vivo evaluation
AbstractOur work tackles the combined advantages of both nanotechnology and the bioadhesive gel properties which were utilized to design an ocular...
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The Influence of Solid/Solvent Interfacial Interactions on Physicochemical and Mechanical Properties of Ofloxacin
PurposeTo investigate the potentials of a simple solvent treatment technique for improving the physicochemical and mechanical properties of ofloxacin.
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Polyvinyl Alcohol/Chitosan Single-Layered and Polyvinyl Alcohol/Chitosan/Eudragit RL100 Multi-layered Electrospun Nanofibers as an Ocular Matrix for the Controlled Release of Ofloxacin: an In Vitro and In Vivo Evaluation
A novel nanofiber insert was prepared with a modified electrospinning method to enhance the ocular residence time of ofloxacin (OFX) and to provide a...
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A meta-analysis on the prevalence of resistance of Staphylococcus aureus to different antibiotics in Nigeria
BackgroundRapid emergence of multidrug resistant Staphylococcus aureus has resulted to difficulty in treatment of infections caused by such strains....
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Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice
Infection with Mycobacterium tuberculosis ( Mtb ) results in the primary formation of a densely packed inflammatory foci that limits entry of...
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Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series
BackgroundPost-vaccination BCG disease typically attests to underlying inborn errors of immunity (IEIs), with the highest rates of complications in...
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Fluoroquinolone susceptibility in first-line drug-susceptible M. tuberculosis isolates in Lima, Peru
ObjectiveTo determine at two distinct time points the prevalence of resistance to ofloxacin (OFX), the representative class drug of fluoroquinolones...
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Direct detection of resistance to fluoroquinolones/SLIDs in sputum specimen by GenoType MTBDRsl v.2.0 assay A study from Eastern Uttar Pradesh, India
BackgroundAccording to World Health Organization (WHO), drug-resistant tuberculosis (DR-TB) is a major contributor to antimicrobial resistance...
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Case report on a swift shift in uropathogens from Shigella flexneri to Escherichia coli: a thin line between bacterial persistence and reinfection
BackgroundUrinary tract infections (UTI) are mostly caused by bacteria. Urine cultures are usually a definitive measure to select the appropriate...
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The Effect of a Mutation in the vapC46 Gene of Mycobacterium tuberculosis on the Functional Activity of the VapC46 Toxin
AbstractToxin-antitoxin (TA) systems are commonly found in most species of bacteria, including the causative agent of tuberculosis M. tuberculosis ....
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Modulating the transcriptomic profile of multidrug-resistant Klebsiella pneumoniae biofilm formation by antibiotics in combination with zinc sulfate
BackgroundKlebsiella pneumoniae is a significant healthcare-associated pathogen. We investigated the antimicrobial interaction pattern between zinc...
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Novel Coumarins Derivatives for A. baumannii Lung Infection Developed by High-Throughput Screening and Reinforcement Learning
With the increasing resistance of Acinetobacter baumannii ( A. baumannii ) to antibiotics, researchers have turned their attention to the development...
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Toward One Health Approach: Linking Enteric Pathogens from Diverse Sources with Widespread Dissemination of Antimicrobial Resistance
One Health is a multidisciplinary concept to provide optimal health for humans and animals and to protect the environment. Antimicrobial resistance...
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Toward One Health Approach: Linking Enteric Pathogens from Diverse Sources with Widespread Dissemination of Antimicrobial Resistance
One Health is a multidisciplinary concept to provide optimal health for humans and animals and to protect the environment. Antimicrobial resistance...
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Evaluation of efflux pump activity and biofilm formation in multidrug resistant clinical isolates of Pseudomonas aeruginosa isolated from a Federal Medical Center in Nigeria
BackgroundPseudomonas aeruginosa an opportunistic pathogen, is widely associated with nosocomial infections and exhibits resistance to multiple...
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News sequences types of Staphylococcus aureus isolated from human pathologicals fluids in Burkina Faso
Staphylococcus aureus is a pathogen with high epidemic potential frequently involved in nosocomials and communities infections. The pathogenicity of St...
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Antibiotic Adjuvant 4-Hexylresorcinol Enhances the Efficiency of Antituberculosis Drugs
We studied the possibility of using 4-hexylresorcinol to increase the efficiency of anti-mycobacterial chemotherapy. In an in vitro experiment,...