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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
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High-precision map** reveals the structure of odor coding in the human brain
Odor perception is inherently subjective. Previous work has shown that odorous molecules evoke distributed activity patterns in olfactory cortices,...
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Olfactory function and discrimination ability in the elderly: a pilot study
We recently reported that subjects with a higher olfactory identification threshold for rose odor declined more in attentional ability in the...
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Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing
The olfactory system’s ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal’s...
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Odor coding in the mammalian olfactory epithelium
Noses are extremely sophisticated chemical detectors allowing animals to use scents to interpret and navigate their environments. Odor detection...
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Adaptive temporal processing of odor stimuli
The olfactory system translates chemical signals into neuronal signals that inform behavioral decisions of the animal. Odors are cues for source...
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Distinct Characteristics of Odor-evoked Calcium and Electrophysiological Signals in Mitral/Tufted Cells in the Mouse Olfactory Bulb
Fiber photometry is a recently-developed method that indirectly measures neural activity by monitoring Ca 2+ signals in genetically-identified...
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Odor hedonics coding in the vertebrate olfactory bulb
Whether an odorant is perceived as pleasant or unpleasant (hedonic value) governs a range of crucial behaviors: foraging, esca** danger, and social...
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Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors
The role of granule cells in olfactory processing is surrounded by several enigmatic observations, such as the purpose of reciprocal spines and the...
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The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection
Understanding non-motor symptoms of Parkinson’s disease is important in order to unravel the underlying molecular mechanisms of the disease....
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Effect of odor pleasantness on heat-induced pain: An fMRI study
Odor modulates the experience of pain, but the neural basis of how the two sensory modalities, olfaction and pain, are linked in the central nervous...
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Natural and Pathological Aging Distinctively Impacts the Pheromone Detection System and Social Behavior
Normal aging and many age-related disorders such as Alzheimer’s disease cause deficits in olfaction; however, it is currently unknown how natural and...
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Learning-dependent plasticity in the antennal lobe improves discrimination and recognition of odors in the honeybee
Honeybees are extensively used to study olfactory learning and memory processes thanks to their ability to discriminate and remember odors and...
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On the Similarity of the Mechanisms of Processing Olfactory, Auditory, and Visual Information in the CNS: A Hypothesis
Abstract —A possible mechanism for processing odors in a neural network that includes the olfactory bulb, the piriform cortex, the olfactory tubercle,...
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Neural dynamics underlying associative learning in the dorsal and ventral hippocampus
Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how...
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Plasticity of Sniffing Pattern and Neural Activity in the Olfactory Bulb of Behaving Mice During Odor Sampling, Anticipation, and Reward
The olfactory bulb (OB) is the first relay station in the olfactory system. In the OB, mitral/tufted cells (M/Ts), which are the main output neurons,...
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Interaction of cholinergic disruption and age on cognitive flexibility in rats
Healthy aging is associated with a functional reduction of the basal forebrain (BF) system that supplies the neurochemical acetylcholine (ACh) to the...
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Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area
Intelligent behavior involves associations between high-dimensional sensory representations and behaviorally relevant qualities such as valence....
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The Role of the Hippocampus in the Perception and Recall of Odors. A Hypothetical Neural Mechanism
A mechanism for the interdependent functioning of the olfactory and hippocampal neural networks is proposed. This functioning involves a significant...