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Disruption of positive- and negative-feature morphine interoceptive occasion setters by dopamine receptor agonism and antagonism in male and female rats
RationaleInternally perceived stimuli evoked by morphine administration can form Pavlovian associations such that they can function as occasion...
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Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters
Reward-seeking in the world is driven by cues that can have ambiguous predictive and motivational value. To produce adaptive, flexible...
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Learning processes in relapse to alcohol use: lessons from animal models
RationaleAlcohol use is reliably preceded by discrete and contextual stimuli which, through diverse learning processes, acquire the capacity to...
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Brain oscillation recordings of the audience in a live concert-like setting
There are only a few previous EEG studies that were conducted while the audience is listening to live music. However, in laboratory settings using...
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Healthcare Professionals’ Views of Working with Medical Interpreters in a Cancer Setting: an Exploratory Study
Australia, like many other nations, continues to become more culturally and linguistically diverse. Medical interpreters play a key role in bridging...
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Challenges in collecting information on sexual orientation and gender identity for cancer patients: perspectives of hospital and central cancer registry abstractors
PurposeSexual and gender minority (SGM) populations experience cancer treatment and survival disparities; however, inconsistent sexual orientation...
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Individualized Patient Care Through Model-Informed Precision Dosing: Reflections on Training Future Practitioners
Prior to his passing, Dr. Roger Jelliffe, expressed the need for educating future physicians and clinical pharmacists on the availability of...
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First-line atezolizumab/durvalumab plus platinum–etoposide combined with radiotherapy in extensive-stage small-cell lung cancer
BackgroundImmunotherapy has made significant advances in the treatment of extensive-stage small-cell lung cancer (ES-SCLC), but data in combination...
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Population Pharmacokinetics of Ibrutinib in Healthy Adults
Background and ObjectivesIbrutinib is an antineoplastic agent that reduces B-cell proliferation by inhibiting Bruton's tyrosine kinase. We describes...
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Assessment of a systematic approach for implementing novel medications in clinical practice: an observational study with dapagliflozin
ObjectiveTo assess a systematic implementation approach for introducing dapagliflozin to individuals with heart failure and reduced ejection fraction...
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Staphylococcus aureus nasal carriage and bloodstream infection among conventional hemodialysis patients in Thailand: a prospective multicenter cohort study
ObjectiveStaphylococcus aureus nasal carriage screening among hemodialysis patients is not standard practice in Thailand, because of data lacking...
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Silas Weir Mitchell on the Cerebellum: Rich Neurophysiological Concepts and a Modern Perspective
Silas Weir Mitchell (1829 – 1914), the Philadelphia-based neurologist, is considered a founding father of American neurology. Mitchell’s 1869 paper...
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Operational characteristics of full random effects modelling (‘frem’) compared to stepwise covariate modelling (‘scm’)
An adequate covariate selection is a key step in population pharmacokinetic modelling. In this study, the automated stepwise covariate modelling...
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Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet
Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health...
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Further variation of the adulticide protocol for the treatment of canine heartworm infection: can it be even shorter and cost less?
BackgroundThis retrospective study evaluated modified three-dose melarsomine treatment protocols in a shelter setting and compared them to the...
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The ad-libitum taste test as measure of momentary alcohol use in the laboratory: an investigation of construct validity and confounding factors
RationaleThe ad-libitum taste test is a widely used covert measure of motivation to consume alcohol in the laboratory. However, studies on its...
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Blockchain in Medical Education
Medical educationMedical education is a course of study directed at acquiring knowledge and skills necessary for preventing and treating disease to...
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Physiotherapy interventions for the treatment of spasticity in people with spinal cord injury: a systematic review
Study designSystematic review.
ObjectiveTo determine the effectiveness of physiotherapy interventions for the treatment of spasticity in people with...
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The Care and Management of Children and Young People with Ataxia Telangiectasia Provided by Nurses and Allied Health Professionals: a Sco** Review
Ataxia telangiectasia (A-T) is a rare, multisystem progressive condition that typically presents in early childhood. In the absence of cure, people...
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The natural history of adults with Rubinstein-Taybi syndrome: a families-reported experience
The existing knowledge about morbidity in adults with Rubinstein-Taybi syndrome (RTS) is limited and detailed data on their natural history and...
