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O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma
BackgroundThe homologous recombination (HR) pathway is involved in DNA damage response (DDR), which is crucial to cancer cell survival after...
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Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro
AbstractThe repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating...
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Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results
MGMT promoter methylation testing is required for prognosis and predicting temozolomide response in gliomas. Accurate results depend on sufficient...
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MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value
Treatment with the alkylating agent temozolomide is known to be prognostically beneficial in a subset of glioblastoma patients. Response to such...
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Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation
A growing body of evidence supports the presence of a population of cells in glioblastoma (GBM) with a stem cell-like phenotype which shares certain...
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WNT signaling modulates chemoresistance to temozolomide in p53-mutant glioblastoma multiforme
Glioblastoma multiforme (GBM) has been characterized by the high incidence, therapy tolerance and relapse. The molecular events controlling GBM...
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Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics
BackgroundPromoter methylation of the DNA repair gene O 6 -methylguanine-DNA methyltransferase ( MGMT ) is an acknowledged predictive epigenetic marker...
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An insertion variant of MGMT disrupts a STAT1 binding site and confers susceptibility to glioma
BackgroundO 6 -methylguanine-DNA methyltransferase (MGMT) is a pivotal enzyme for repairing DNA alkylation damage. Epigenetic modification of MGMT has...
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Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins
BackgroundEpigenetic inactivation of O 6 -methylguanine DNA-methyltransferase ( MGMT ) is associated with increased sensitivity to alkylating...
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ELEVATE – evaluating Temozolomide and Nivolumab in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma with MGMT methylation: study protocol for a single arm phase II trial
BackgroundFor patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which...
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Molecular features of glioblastomas in long-term survivors compared to short-term survivors—a matched-pair analysis
BackgroundAlthough glioblastoma (GB) is associated with a devastating prognosis, a small proportion of patients achieve long-term survival rates. We...
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A randomised phase II trial of temozolomide with or without cannabinoids in patients with recurrent glioblastoma (ARISTOCRAT): protocol for a multi-centre, double-blind, placebo-controlled trial
BackgroundGlioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 per year in England. Patients with...
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High-dose radiotherapy in newly diagnosed low-grade gliomas with nonmethylated O(6)-methylguanine-DNA methyltransferase
BackgroundPatients with low-grade gliomas (LGGs) harboring O 6 -methylguanine-DNA methyltransferase promoter nonmethylation ( MGMT -non-pM) have a...
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O6-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms
BackgroundStreptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic...
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Development of Tumor-Induced Bystander Effect and Radiosensitivity in the Peripheral Blood Lymphocytes of Glioblastoma Patients with Different MGMT Gene Methylation Statuses in Tumor Cells
AbstractThe effect of the MGMT gene methylation in glioblastoma cells on the development of the tumor-induced bystander effect and the modification...
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Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection...
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Assessment of MGMT methylation status using high-performance liquid chromatography in newly diagnosed glioblastoma
BackgroundThe utility of O 6 -methylguanine-DNA methyltransferase (MGMT) gene promoter methylation status as a prognostic marker in patients with...
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DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastoma
DNA methylation is crucial for chromatin structure and gene expression and its aberrancies, including the global “hypomethylator phenotype”, are...
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Putting a Magnifying Lens on Pharmacogenetics and Pharmacogenomics Associated Challenges and Opportunities in Area of Cancer Research
In cancer research, pharmacogenetics and pharmacogenomics are develo** fields that have the capability to have a huge impact on cancer healthcare...
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Immune cell infiltration and inflammatory landscape in primary brain tumours
BackgroundPrimary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer...
